University of Southern California, Los Angeles, CA 90089-9176, USA.
Trends Immunol. 2019 Aug;40(8):668-670. doi: 10.1016/j.it.2019.06.007. Epub 2019 Jul 13.
Evolutionarily, how RAG endonucleases in vertebrate immune systems could shed dangerous transposon-like propensities, and instead, support the organized assembly of antigen receptor variable domains, has been unclear. Recent structural work by Schatz and colleagues (Nature, 2019) identifies features of the RAG endonuclease deemed to be key in supporting this critical change in vertebrate advancement.
从进化的角度来看,脊椎动物免疫系统中的 RAG 内切酶如何摆脱危险的转座子倾向,转而支持抗原受体可变域的有序组装,这一点一直不清楚。Schatz 及其同事最近的结构研究(《自然》,2019 年)确定了 RAG 内切酶的一些特征,这些特征被认为是支持脊椎动物进化中这一关键变化的关键。