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巨细胞动脉炎伴节段性视盘水肿及视力正常两例

Two Cases of Segmental Disc Oedema and Normal Visual Acuity in Giant Cell Arteritis.

作者信息

Donaldson Laura, Shemesh Ari Aharon, Margolin Edward

机构信息

Department of Ophthalmology, McMaster University, Hamilton, Ontario, Canada.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

出版信息

Neuroophthalmology. 2018 Jul 24;43(3):201-204. doi: 10.1080/01658107.2018.1490778. eCollection 2019 Jun.

Abstract

Giant cell arteritis (GCA) frequently involves the ocular circulation. Arteritic anterior ischemic optic neuropathy (AAION) is the most common presentation, producing severe vision loss with a characteristic waxy pallor of the optic disc. Optic disc ischemia in AAION is related to underlying systemic vasculitis, which must be treated aggressively with systemic steroids in order to minimize the risk of fellow eye involvement. In contrast, non-arteritic AION (NAION) is thought to result from localized hypoperfusion of the posterior ciliary arteries and mainly presents with segmental optic disc oedema. This condition is usually seen in individuals with crowded optic discs as well as predisposing vascular risk factors and does not require specific treatment. Distinguishing these two entities is important and often challenging. We describe two cases of biopsy-confirmed AAION presenting as segmental disc oedema with the absence of pallor, suggesting specific and isolated involvement of the posterior ciliary arteries in GCA affecting the ophthalmic circulation. This emphasizes the importance of maintaining a high index of suspicion for GCA, particularly when atypical features are present or systemic findings accompany acute vision loss.

摘要

巨细胞动脉炎(GCA)常累及眼循环。动脉炎性前部缺血性视神经病变(AAION)是最常见的表现形式,可导致严重视力丧失,并伴有视盘特征性的蜡样苍白。AAION中的视盘缺血与潜在的全身性血管炎有关,必须积极使用全身性类固醇进行治疗,以将对侧眼受累的风险降至最低。相比之下,非动脉炎性前部缺血性视神经病变(NAION)被认为是由睫状后动脉局部灌注不足引起的,主要表现为节段性视盘水肿。这种情况通常见于视盘拥挤以及存在易患血管危险因素的个体,不需要特殊治疗。区分这两种情况很重要,且往往具有挑战性。我们描述了两例经活检证实的AAION病例,其表现为节段性视盘水肿且无苍白,提示GCA中睫状后动脉出现特异性和孤立性受累,影响眼循环。这强调了对GCA保持高度怀疑的重要性,尤其是当出现非典型特征或急性视力丧失伴有全身表现时。

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Two Cases of Segmental Disc Oedema and Normal Visual Acuity in Giant Cell Arteritis.巨细胞动脉炎伴节段性视盘水肿及视力正常两例
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