Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Department of Chemical Biology & Therapeutics, Institute of Nano Science & Technology, Habitat Centre, Phase 10, Sector 64, Mohali, Punjab, India.
Nanomedicine (Lond). 2019 Jul;14(14):1911-1927. doi: 10.2217/nnm-2018-0448. Epub 2019 Jul 17.
Visceral leishmaniasis (VL) is a life-threatening parasitic disease affecting impoverished people of the developing world; and much effort has been spent on the early case detection and treatment. However, current diagnostics and treatment options are not sufficient for appropriate surveillance in VL elimination setting. Hence, there is a dire need to develop highly sensitive diagnostics and less toxic effective treatments for proper management of cases and to achieve the sustained disease elimination. Although, promising results have been observed with nanomedicines in leishmaniasis; there are great challenges ahead especially in translating this to clinical setting. This review provides updated progress of nanomedicines in VL, and discussed how these innovations and future directions play vital role in achieving VL elimination.
内脏利什曼病（VL）是一种危及生命的寄生虫病，影响发展中国家的贫困人群；人们为早期病例检测和治疗付出了巨大努力。然而，目前的诊断和治疗选择不足以在 VL 消除环境中进行适当监测。因此，迫切需要开发高度敏感的诊断方法和毒性更小的有效治疗方法，以妥善管理病例并实现持续消除疾病。尽管纳米医学在利什曼病方面取得了有希望的结果，但仍面临巨大挑战，特别是在将其转化为临床环境方面。本文综述了纳米医学在 VL 中的最新进展，并讨论了这些创新和未来方向如何在实现 VL 消除方面发挥重要作用。
