Reed C E, Marcoux J P, Welsh P W
Division of Allergic Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
J Allergy Clin Immunol. 1988 May;81(5 Pt 2):1042-7. doi: 10.1016/0091-6749(88)90177-7.
During the ragweed season of 1984 we studied 120 patients with hay fever; 58 had a history of asthma during the ragweed season the year before. They were divided into four treatment groups to receive nasal sprays of placebo, cromolyn sodium, flunisolide, or beclomethasone. In controlling hay fever symptoms all medications were superior to placebo; the glucocorticoids were more effective than was cromolyn sodium. Chest symptoms in the 58 patients with a history of asthma were also relieved by the topical nasal treatment. Various explanations for the beneficial effect of topical nasal treatment in asthma symptoms are conceivable. We consider the most likely to be improvement of nasal airway function. With restoration of the filtering action of the nose, less allergen would penetrate to the intrathoracic airways because of reduction in mouth breathing.
在1984年豚草季节，我们研究了120例花粉症患者；其中58例在前一年豚草季节有哮喘病史。他们被分为四个治疗组，分别接受安慰剂、色甘酸钠、氟尼缩松或倍氯米松的鼻喷雾剂治疗。在控制花粉症症状方面，所有药物均优于安慰剂；糖皮质激素比色甘酸钠更有效。58例有哮喘病史患者的胸部症状也通过局部鼻治疗得到缓解。对于局部鼻治疗对哮喘症状有益作用的各种解释是可以想象的。我们认为最有可能的是鼻气道功能的改善。随着鼻子过滤功能的恢复，由于口呼吸减少，较少的变应原会渗透到胸内气道。
