Department of Food Science, Cornell University, Ithaca, NY 14853, USA.
Toxins (Basel). 2019 Jul 16;11(7):416. doi: 10.3390/toxins11070416.
A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of , including the structure and function of these toxins and our current understanding of their contributions to virulence.
许多致病菌利用毒素在易感宿主中引发疾病。食源性病原体 是最重要和研究最充分的细菌病原体之一。最近，全基因组序列特征分析揭示了多种血清型编码的多种新型 ADP-ribosylating 毒素的存在。在这篇综述中，我们讨论了 的经典（SpvB）和新型（伤寒毒素、ArtAB 和 SboC/SeoC）ADP-ribosylating 毒素，包括这些毒素的结构和功能以及我们对它们在毒力中的作用的现有认识。
