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纳米技术的新时代，一种改变癌症治疗的替代方法。

The new era of nanotechnology, an alternative to change cancer treatment.

作者信息

Jurj Ancuta, Braicu Cornelia, Pop Laura-Ancuta, Tomuleasa Ciprian, Gherman Claudia Diana, Berindan-Neagoe Ioana

机构信息

Research Center for Functional Genomics, Biomedicine and Translational Medicine, University of Medicine and Pharmacy "Iuliu-Hatieganu", Cluj-Napoca, Romania.

Department of Hematology, The Oncology Institute "Prof Dr Ion Chiricuta", Cluj-Napoca, Romania.

出版信息

Drug Des Devel Ther. 2017 Sep 27;11:2871-2890. doi: 10.2147/DDDT.S142337. eCollection 2017.

DOI:10.2147/DDDT.S142337
PMID:29033548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628667/
Abstract

In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.

摘要

在过去几年中，纳米结构在治疗剂的安全递送方面引起了广泛关注。已经报道了几种治疗方法，如分子诊断、疾病检测、纳米级免疫疗法和抗癌药物递送，这些方法有望应用于临床。本文旨在强调支持使用与不同类型治疗剂缀合的纳米颗粒的背景，这些纳米颗粒适用于靶向治疗和癌症研究，尤其侧重于血液系统恶性肿瘤。一个特别关键的点是非病毒递送系统的功能表征，如金纳米颗粒、脂质体和树枝状大分子。本文还展示了与在癌症治疗中使用纳米颗粒递送微小RNA和RNA干扰相关的已发表的相关数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/7a8053e87366/dddt-11-2871Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/eae7c5f944ff/dddt-11-2871Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/603fc91237d6/dddt-11-2871Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/6a35ddefb9a1/dddt-11-2871Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/5244741947c4/dddt-11-2871Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/0e7532bec3a8/dddt-11-2871Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/7a8053e87366/dddt-11-2871Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/eae7c5f944ff/dddt-11-2871Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/603fc91237d6/dddt-11-2871Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/6a35ddefb9a1/dddt-11-2871Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/5244741947c4/dddt-11-2871Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/0e7532bec3a8/dddt-11-2871Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c74/5628667/7a8053e87366/dddt-11-2871Fig6.jpg

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