小梁网再生——青光眼的一种潜在治疗方法。
Trabecular Meshwork Regeneration - A Potential Treatment for Glaucoma.
作者信息
Castro Alexander, Du Yiqin
机构信息
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213.
University of Virginia, Charlottesville, VA 22904.
出版信息
Curr Ophthalmol Rep. 2019 Jun;7(2):80-88. doi: 10.1007/s40135-019-00203-2. Epub 2019 Apr 16.
Abstract
PURPOSE
In this review, we overview the pathophysiology of primary open-angle glaucoma as it relates to the trabecular meshwork (TM), exploring modes of TM dysfunction and regeneration via stem cell therapies.
RECENT FINDINGS
Stem cells from a variety of sources, including trabecular meshwork, mesenchymal, adipose and induced pluripotent stem cells, have shown the potential to differentiate into TM cells or and to regenerate the TM , lowering intraocular pressure (IOP) and reducing glaucomatous retinal ganglion cell damage.
SUMMARY
Stem cell therapies for TM regeneration provide a robust and promising suite of treatments for eventual lowering of IOP and prevention of glaucomatous vision loss in humans in the future. Further investigation into stem cell homing mechanisms and the safety of introducing these cells into human anterior chamber, for instance, are required before clinical applications in treating glaucoma patients.
摘要
目的
在本综述中，我们概述了与小梁网（TM）相关的原发性开角型青光眼的病理生理学，探讨小梁网功能障碍的模式以及通过干细胞疗法实现小梁网再生的方式。
最新发现
来自多种来源的干细胞，包括小梁网干细胞、间充质干细胞、脂肪干细胞和诱导多能干细胞，已显示出分化为小梁网细胞以及使小梁网再生的潜力，可降低眼压（IOP）并减少青光眼性视网膜神经节细胞损伤。
总结
用于小梁网再生的干细胞疗法为未来最终降低眼压和预防人类青光眼性视力丧失提供了一系列强有力且有前景的治疗方法。例如，在将这些细胞应用于青光眼患者的临床治疗之前，还需要进一步研究干细胞归巢机制以及将这些细胞引入人眼前房的安全性。
相似文献
1
Trabecular Meshwork Regeneration - A Potential Treatment for Glaucoma.小梁网再生——青光眼的一种潜在治疗方法。
Curr Ophthalmol Rep. 2019 Jun;7(2):80-88. doi: 10.1007/s40135-019-00203-2. Epub 2019 Apr 16.
2
Replacement of the Trabecular Meshwork Cells-A Way Ahead in IOP Control?小梁网细胞置换——眼压控制的新途径？
Biomolecules. 2021 Sep 16;11(9):1371. doi: 10.3390/biom11091371.
3
A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork.一种新的青光眼治疗方法：小梁网干细胞再生。
Prog Retin Eye Res. 2022 Sep;90:101063. doi: 10.1016/j.preteyeres.2022.101063. Epub 2022 Apr 6.
4
Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.诱导多能干细胞衍生的小梁网细胞移植可在体内挽救青光眼表型。
Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3492-500. doi: 10.1073/pnas.1604153113. Epub 2016 Jun 6.
5
Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma.基于细胞的小梁网再生疗法治疗青光眼。
Biomolecules. 2021 Aug 24;11(9):1258. doi: 10.3390/biom11091258.
6
Stem Cells in the Trabecular Meshwork for Regulating Intraocular Pressure.小梁网中的干细胞用于调节眼压
J Ocul Pharmacol Ther. 2016 Jun;32(5):253-60. doi: 10.1089/jop.2016.0005. Epub 2016 May 16.
7
Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.眼前段与晶状体白内障和原发性开角型青光眼小梁网损伤相关的氧化应激的生物标志物和特殊特征：用 N-乙酰基肉碱润眼液和未水解肉碱口服制剂进行双重联合治疗的挑战。
Fundam Clin Pharmacol. 2012 Feb;26(1):86-117. doi: 10.1111/j.1472-8206.2011.00969.x. Epub 2011 Aug 24.
8
Effects of Trabecular Meshwork Width and Schlemm's Canal Area on Intraocular Pressure Reduction in Glaucoma Patients.小梁网宽度和施莱姆氏管面积对青光眼患者眼压降低的影响。
Korean J Ophthalmol. 2021 Aug;35(4):311-317. doi: 10.3341/kjo.2021.0007. Epub 2021 Jun 21.
9
A Porcine Organ-Culture Glaucoma Model Mimicking Trabecular Meshwork Damage Using Oxidative Stress.一种利用氧化应激模拟小梁网损伤的猪器官培养青光眼模型
Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):18. doi: 10.1167/iovs.62.3.18.
10
Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma.小梁细胞衰老表型在原发性开角型青光眼中有生物标志物表现。
Curr Mol Med. 2011 Oct;11(7):528-52. doi: 10.2174/156652411800615126.
引用本文的文献
1
In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics.小鼠眼前房和后房容积的体内定量：对房水动力学的影响
Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):18. doi: 10.1167/iovs.66.1.18.
2
Trabecular Meshwork Stem Cells for Glaucoma Treatment.用于治疗青光眼的小梁网干细胞。
Methods Mol Biol. 2025;2858:143-158. doi: 10.1007/978-1-0716-4140-8_13.
3
Association Between Glucagon-Like Peptide-1 Receptor Agonists Exposure and Intraocular Pressure Change: GLP-1 Receptor Agonists and Intraocular Pressure Change.胰高血糖素样肽-1受体激动剂暴露与眼压变化之间的关联：胰高血糖素样肽-1受体激动剂与眼压变化
Am J Ophthalmol. 2025 Jan;269:255-265. doi: 10.1016/j.ajo.2024.08.030. Epub 2024 Sep 3.
4
quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics.小鼠前房和后房容积的量化：对房水动力学的影响
bioRxiv. 2024 Jul 25:2024.07.24.604989. doi: 10.1101/2024.07.24.604989.
5
iPSCs-Based Therapy for Trabecular Meshwork.基于诱导多能干细胞的小梁网治疗
Handb Exp Pharmacol. 2023;281:277-300. doi: 10.1007/164_2023_671.
6
Recreating the Trabecular Outflow Tissue on Implantable, Micropatterned, Ultrathin, Porous Polycaprolactone Scaffolds.在可植入的、微图案化的、超薄的、多孔聚己内酯支架上重建小梁流出组织。
Bioengineering (Basel). 2023 Jun 2;10(6):679. doi: 10.3390/bioengineering10060679.
7
The Catcher in the Eye: Stem Cells as a Therapeutic for Glaucoma.眼中的守望者：干细胞作为青光眼的一种治疗方法
Ophthalmol Glaucoma. 2023 Jan-Feb;6(1):1-3. doi: 10.1016/j.ogla.2022.07.004. Epub 2022 Aug 18.
8
A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork.一种新的青光眼治疗方法：小梁网干细胞再生。
Prog Retin Eye Res. 2022 Sep;90:101063. doi: 10.1016/j.preteyeres.2022.101063. Epub 2022 Apr 6.
9
Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines.重组细胞因子体外诱导人诱导多能干细胞向小梁网样细胞分化：无饲养层和动物来源成分。
Transl Vis Sci Technol. 2021 May 3;10(6):27. doi: 10.1167/tvst.10.6.27.
10
Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma.锂与非典型抗精神病药物：青光眼可能的WNT/β信号通路靶点
Biomedicines. 2021 Apr 26;9(5):473. doi: 10.3390/biomedicines9050473.
本文引用的文献
1
Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model.在小鼠模型中，人类干细胞归巢至并修复激光损伤的小梁网。
Commun Biol. 2018 Dec 6;1:216. doi: 10.1038/s42003-018-0227-z. eCollection 2018.
2
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma.间质干细胞衍生的小细胞外囊泡促进 DBA/2J 型青光眼遗传小鼠模型的神经保护作用。
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5473-5480. doi: 10.1167/iovs.18-25310.
3
Regenerating Eye Tissues to Preserve and Restore Vision.再生眼部组织以保护和恢复视力。
Cell Stem Cell. 2018 Sep 6;23(3):453. doi: 10.1016/j.stem.2018.08.014.
4
Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension.Rho 激酶抑制剂治疗青光眼和高眼压症的新策略。
Ophthalmology. 2018 Nov;125(11):1741-1756. doi: 10.1016/j.ophtha.2018.04.040. Epub 2018 Jul 12.
5
Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis.间充质基质细胞衍生的细胞外囊泡：再生和免疫调节作用及其在脓毒症中的潜在应用。
Cell Tissue Res. 2018 Oct;374(1):1-15. doi: 10.1007/s00441-018-2871-5. Epub 2018 Jun 28.
6
The relationship between outflow resistance and trabecular meshwork stiffness in mice.小鼠眼外流出阻力与小梁网硬度的关系。
Sci Rep. 2018 Apr 11;8(1):5848. doi: 10.1038/s41598-018-24165-w.
7
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.关于小梁网细胞分离、鉴定和培养的共识建议。
Exp Eye Res. 2018 Jun;171:164-173. doi: 10.1016/j.exer.2018.03.001. Epub 2018 Mar 9.
8
Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork.人眼小梁组织多能祖细胞的分离和扩增。
Sci Rep. 2018 Feb 12;8(1):2814. doi: 10.1038/s41598-018-21098-2.
9
Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma.间质干细胞衍生的小细胞外囊泡促进青光眼啮齿动物模型的神经保护作用。
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):702-714. doi: 10.1167/iovs.17-22855.
10
Prdx6 retards senescence and restores trabecular meshwork cell health by regulating reactive oxygen species.过氧化物还原酶6通过调节活性氧延缓衰老并恢复小梁网细胞健康。
Cell Death Discov. 2017 Sep 11;3:17060. doi: 10.1038/cddiscovery.2017.60. eCollection 2017.
Zotero 插件