密码子偏好反映了错译限制：一项提议。
Codon preference reflects mistranslational constraints: a proposal.
作者信息
McPherson D T
机构信息
Monsanto Company, St Louis, MO 63198.
出版信息
Nucleic Acids Res. 1988 May 11;16(9):4111-20. doi: 10.1093/nar/16.9.4111.
Abstract
Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.
摘要
在观察到赖氨酸在较差选择密码子精氨酸-AGA处误掺入精氨酸后，对大肠杆菌中高表达mRNA的密码子使用模式进行比较，为以下提议提供了依据：主要密码子偏好受到错译限制。此外，密码子的使用和排列方式，是为了提供一种亲水性保守氨基酸，作为错译事件最可能产生的替代物。
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本文引用的文献
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2
Nonrandom patterns of codon usage and of nucleotide substitutions in human alpha- and beta-globin genes: an evolutionary strategy reducing the rate of mutations with drastic effects?人类α-和β-珠蛋白基因中密码子使用和核苷酸替换的非随机模式：一种降低具有严重影响的突变率的进化策略？
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1110-4. doi: 10.1073/pnas.78.2.1110.
3
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