Yarus M
Science. 1982 Nov 12;218(4573):646-52. doi: 10.1126/science.6753149.
Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.
转运RNA可能在翻译效率方面受到非常强烈的选择。在本文中，有人提出三联体反密码子的编码性能通过选择匹配的反密码子环和茎序列而得到增强。因此，反密码子加上这些附近的序列特征（扩展反密码子）比单独的反密码子包含更多的编码信息，并且在核糖体上能够更高效、准确地发挥作用。这一观点成功地解释了许多转运RNA的相对效率。
