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褪黑素受体MT1和MT2在非小细胞肺癌（NSCLC）中的预后影响

Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung Cancer (NSCLC).

作者信息

Jablonska Karolina, Nowinska Katarzyna, Piotrowska Aleksandra, Partynska Aleksandra, Katnik Ewa, Pawelczyk Konrad, Glatzel-Plucinska Natalia, Podhorska-Okolow Marzenna, Dziegiel Piotr

机构信息

Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Department of Thoracic Surgery, Wroclaw Medical University, 53-439 Wroclaw, Poland.

出版信息

Cancers (Basel). 2019 Jul 17;11(7):1001. doi: 10.3390/cancers11071001.

DOI:10.3390/cancers11071001
PMID:31319607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6679108/
Abstract

: Several studies have investigated the inhibitory effect of melatonin on lung cancer cells. There are no data available on the prognostic impact of melatonin receptors MT1 and MT2 in non-small cell lung cancer (NSCLC). : Immunohistochemical studies of MT1 and MT2 were conducted on NSCLC (N = 786) and non-malignant lung tissue (NMLT) (N = 120) using tissue microarrays. Molecular studies were performed on frozen fragments of NSCLC (N = 62; real time PCR), NMLT (N = 24) and lung cancer cell lines NCI-H1703, A549 and IMR-90 (real time PCR, western blot). : The expression of both receptors was higher in NSCLC than in NMLT. Higher MT1 and MT2 expression levels (at protein and mRNA) were noted in squamous cell carcinomas (SCC) compared to adenocarcinomas (AC). MT1 immunoexpression decreased as both the tumour size and the cancer stage increased in the whole cohort, while MT2 decreased as the cancer stage increased, with lymph node involvement (in the whole study group) and increasing malignancy grade (in SCC). Higher expression of MT2 was associated with a favorable prognosis. MT2 was an independent prognostic factor for overall survival (OS) in all analyzed NSCLC and in smoking patients. : Our observations may point to the potential prognostic significance of MT2 in NSCLC.

摘要

多项研究调查了褪黑素对肺癌细胞的抑制作用。目前尚无关于褪黑素受体MT1和MT2在非小细胞肺癌（NSCLC）中的预后影响的数据。

使用组织微阵列对NSCLC（N = 786）和非恶性肺组织（NMLT）（N = 120）进行MT1和MT2的免疫组织化学研究。对NSCLC（N = 62；实时PCR）、NMLT（N = 24）以及肺癌细胞系NCI-H1703、A549和IMR-90的冷冻片段进行分子研究（实时PCR、蛋白质印迹法）。

两种受体在NSCLC中的表达均高于NMLT。与腺癌（AC）相比，鳞状细胞癌（SCC）中MT1和MT2的表达水平（蛋白质和mRNA水平）更高。在整个队列中，MT1免疫表达随着肿瘤大小和癌症分期的增加而降低，而MT2随着癌症分期的增加而降低，伴有淋巴结受累（在整个研究组中）以及恶性程度增加（在SCC中）。MT2的高表达与良好的预后相关。MT2是所有分析的NSCLC以及吸烟患者总生存期（OS）的独立预后因素。

我们的观察结果可能表明MT2在NSCLC中具有潜在的预后意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/3af0c0492aa3/cancers-11-01001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/d4b6e996b93d/cancers-11-01001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/f04dc536e440/cancers-11-01001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/fa7645db4342/cancers-11-01001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/b5597bd30e00/cancers-11-01001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/6a3d776d9c1f/cancers-11-01001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/3af0c0492aa3/cancers-11-01001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/d4b6e996b93d/cancers-11-01001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/f04dc536e440/cancers-11-01001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/fa7645db4342/cancers-11-01001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/b5597bd30e00/cancers-11-01001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/6a3d776d9c1f/cancers-11-01001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0977/6679108/3af0c0492aa3/cancers-11-01001-g006.jpg

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