Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, Victoria, Australia.
Deakin University, Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Geelong, Victoria, Australia; Australian Institute for Musculoskeletal Science (AIMSS), St. Albans, Melbourne, Victoria, Australia.
Exp Gerontol. 2019 Oct 1;125:110662. doi: 10.1016/j.exger.2019.110662. Epub 2019 Jul 16.
Stressful experiences, poor self-rated health, and negative emotional states have been implicated with higher levels of inflammatory markers and lower levels of neurotrophic factors in some healthy adults and clinical populations, but these relationships are unclear in the elderly. This study aimed to identify the associations between systemic inflammatory and neurological markers with well-being and health-related quality of life (HR-QoL) in independently living elderly people.
Cross-sectional study.
A total of 268 men and women aged ≥65 years living independently in retirement communities in Melbourne, Australia.
Questionnaires were used to assess HR-QoL [Short Form (SF)-36 version 2] and well-being (Personal Wellbeing Index). Serum inflammatory cytokines [interleukin (IL)-4, IL-6, IL-1β, IL-8, IL-10, tumor necrosis factor (TNF)-α, and high sensitive C-reactive protein (hs-CRP)] were standardised to Z-scores and used to calculate pro- and anti-inflammatory composite score and an overall composite inflammatory index. Plasma levels of the neurological markers amyloid β (1-40) and amyloid β (1-42), brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), were also assessed.
No significant associations were found between any inflammatory or neurological marker with HR-OoL or well-being, with the exception that lower perceptions of the HR-QoL vitality subscale were associated with higher levels of hs-CRP [unstandardized beta-coefficient (β): -1.50; 95% CI: -2.53, -0.46; P = 0.004] and Z-scores in the pro-inflammatory composite score (β = -2.06; 95% CI: -3.49, -0.62; P = 0.005).
CONCLUSIONS/IMPLICATIONS: In elderly people residing in independent living retirement communities, there was no consistent evidence indicating that circulating inflammatory or neurological markers were associated with the key physical or mental HR-QoL domains or overall well-being. This suggests that these biomarkers may not be effective predictors in relatively healthy communities, and may be more beneficial in frail or clinical populations. Clinical Trials registry: Australian New Zealand Clinical Trials Registry (ACTRN12613001161718). http://www.anzctr.org.au/.
在一些健康成年人和临床人群中，压力经历、自我评估健康状况差和负面情绪状态与炎症标志物水平升高和神经营养因子水平降低有关，但这些关系在老年人中尚不清楚。本研究旨在确定系统炎症和神经标志物与独立生活的老年人的幸福感和健康相关生活质量（HR-QoL）之间的关系。
横断面研究。
共纳入 268 名年龄≥65 岁、居住在澳大利亚墨尔本退休社区的独立老年人。
使用问卷评估 HR-QoL[短格式（SF）-36 版本 2]和幸福感（个人幸福感指数）。将血清炎症细胞因子[白细胞介素（IL）-4、IL-6、IL-1β、IL-8、IL-10、肿瘤坏死因子（TNF）-α 和高敏 C 反应蛋白（hs-CRP）]标准化为 Z 分数，并用于计算促炎和抗炎复合评分以及整体炎症复合指数。还评估了神经标志物β淀粉样蛋白（1-40）和β淀粉样蛋白（1-42）、脑源性神经营养因子（BDNF）、胰岛素样生长因子-1（IGF-1）和血管内皮生长因子（VEGF）的血浆水平。
除了较低的 HR-QoL 活力亚量表与 hs-CRP 水平较高有关（未标准化β系数（β）：-1.50；95%置信区间：-2.53，-0.46；P=0.004）和促炎复合评分的 Z 分数较高（β=-2.06；95%置信区间：-3.49，-0.62；P=0.005）外，没有任何炎症或神经标志物与 HR-QoL 或幸福感之间存在显著关联。
结论/意义：在居住在独立生活退休社区的老年人中，没有一致的证据表明循环炎症或神经标志物与关键的身体或心理 HR-QoL 领域或整体幸福感有关。这表明这些生物标志物在相对健康的人群中可能不是有效的预测指标，而在体弱或临床人群中可能更有益。临床试验注册：澳大利亚和新西兰临床试验注册（ACTRN12613001161718）。http://www.anzctr.org.au/。
