Alghazali Karrer M, Hamzah Rabab N, Nima Zeid A, Steiner Richard, Dhar Madhu, Anderson David E, Hayar Abdallah, Griffin Robert J, Biris Alexandru S
Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nanomaterials (Basel). 2019 Jul 18;9(7):1029. doi: 10.3390/nano9071029.
Gold nanosystems have been investigated extensively for a variety of applications, from specific cancer cell targeting to tissue regeneration. Specifically, a recent and exciting focus has been the gold nanosystems' interface with neuronal biology. Researchers are investigating the ability to use these systems neuronal applications ranging from the enhancement of stem cell differentiation and therapy to stimulation or inhibition of neuronal activity. Most of these new areas of research are based on the integration of the plasmonic properties of such nanosystems into complex synthetic extracellular matrices (ECM) that can interact and affect positively the activity of neuronal cells. Therefore, the ability to integrate the plasmonic properties of these nanoparticles into multidimensional and morphological structures to support cellular proliferation and activity is potentially of great interest, particularly to address medical conditions that are currently not fully treatable. This review discusses some of the promising developments and unique capabilities offered by the integration of plasmonic nanosystems into morphologically complex ECM devices, designed to control and study the activity of neuronal cells.
金纳米系统已被广泛研究用于各种应用，从特定癌细胞靶向到组织再生。具体而言，最近一个令人兴奋的焦点是金纳米系统与神经生物学的界面。研究人员正在研究利用这些系统进行神经应用的能力，范围从增强干细胞分化和治疗到刺激或抑制神经元活动。这些新的研究领域大多基于将此类纳米系统的等离子体特性整合到复杂的合成细胞外基质（ECM）中，这种基质可以与神经元细胞相互作用并对其活动产生积极影响。因此，将这些纳米颗粒的等离子体特性整合到多维和形态结构中以支持细胞增殖和活动的能力可能具有极大的吸引力，特别是对于解决目前尚未完全可治疗的医疗状况。本综述讨论了将等离子体纳米系统整合到形态复杂的ECM装置中所带来的一些有前景的发展和独特能力，这些装置旨在控制和研究神经元细胞的活动。
