Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Omid Cancer Research Center, Omid Preventive and Health Promotion Center, Golestan University of Medical Sciences, Gorgan, Iran.
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Cancer Epidemiol. 2019 Oct;62:101573. doi: 10.1016/j.canep.2019.101573. Epub 2019 Jul 19.
Breast cancer is the most frequent cancer among women worldwide. Breast cancer incidence in young women is a health issue of concern, especially in middle-income countries such as Iran. The aim of this study is to report the breast cancer incidence variations in Golestan province, Iran, over a 10-year period (2004-2013).
We analyzed data from the Golestan Population-based Cancer Registry (GPCR), which is a high-quality cancer registry collecting data on primary cancers based on standard protocols throughout the Golestan province. Age-standardized incidence rates (ASRs) and age-specific incidence rates per 100,000 person-years were calculated. Time trends in ASRs and age-specific rates were evaluated using Joinpoint regressions. The average annual percentage change (AAPC) with correspondence 95% confidence intervals (95%CIs) were calculated.
A total of 2106 new breast cancer cases were diagnosed during the study period. Most cases occurred in women living in urban areas: 1449 cases (68%) versus 657 cases (31%) in rural areas. Statistically significant increasing trends were observed over the 10-year study period amongst women of all ages (AAPC = 4.4; 95%CI: 1.2-7.8) as well as amongst women in the age groups 20-29 years (AAPC = 10.0; 95%CI: 1.7-19.0) and 30-39 years (AAPC = 5.1; 95%CI: 1.4-9.0).
The incidence of breast cancer increased between 2004 and 2013 in Golestan province amongst all age groups, and in particular amongst women aged 20-39 years. Breast cancer should be considered a high priority for health policy making in our community.
乳腺癌是全世界女性中最常见的癌症。年轻女性乳腺癌的发病率是一个令人关注的健康问题，特别是在伊朗等中等收入国家。本研究旨在报告伊朗戈勒斯坦省在 10 年期间（2004-2013 年）乳腺癌发病率的变化。
我们分析了戈勒斯坦基于人群的癌症登记处（GPCR）的数据，该登记处是一个高质量的癌症登记处，根据标准协议在整个戈勒斯坦省收集原发性癌症的数据。计算了年龄标准化发病率（ASR）和每 10 万人年的年龄特异性发病率。使用 Joinpoint 回归评估 ASR 和年龄特异性率的时间趋势。计算了平均年百分比变化（AAPC）及其对应 95%置信区间（95%CI）。
在研究期间共诊断出 2106 例新乳腺癌病例。大多数病例发生在居住在城市地区的女性中：1449 例（68%）与农村地区的 657 例（31%）。在整个 10 年研究期间，所有年龄段的女性以及 20-29 岁（AAPC=10.0；95%CI：1.7-19.0）和 30-39 岁（AAPC=5.1；95%CI：1.4-9.0）年龄组的女性中均观察到统计学上显著的上升趋势。
在戈勒斯坦省，2004 年至 2013 年间，所有年龄段的乳腺癌发病率均有所增加，尤其是 20-39 岁的女性。在我们的社区中，乳腺癌应被视为制定卫生政策的高度优先事项。
