恶性肿瘤患者蛋白尿的患病率、浓度及预后重要性
Prevalence, concentration, and prognostic importance of proteinuria in patients with malignancies.
作者信息
Sawyer N, Wadsworth J, Wijnen M, Gabriel R
机构信息
Renal Unit, St Mary's Hospital, London.
出版信息
Br Med J (Clin Res Ed). 1988 May 7;296(6632):1295-8. doi: 10.1136/bmj.296.6632.1295.
Abstract
Protein was found significantly more frequently in single urine samples from 504 patients with malignancy (290; 58%) than in 529 controls (119; 22%) (p less than 0.01). Median protein concentration was greater (p less than 0.001) in patients with neoplasia (0.14 g/l) than in controls (0.07 g/l). Actuarial analysis showed a median survival of 4.5 months in patients with proteinuria compared with 10 months in those without (p less than 0.001). The association between proteinuria and shorter survival was statistically significant for patients with gut tumours, lung tumours, and tumours at other sites analysed as a group. Patients with myeloma or urinary tract tumours were not studied. In many patients with malignancy the presence of proteinuria may be associated with a substantially reduced survival time.
摘要
在504例恶性肿瘤患者的单次尿液样本中发现蛋白质的频率（290例；58%）显著高于529例对照者（119例；22%）（p<0.01）。肿瘤患者的蛋白质中位数浓度（0.14g/l）高于对照者（0.07g/l）（p<0.001）。精算分析显示，蛋白尿患者的中位生存期为4.5个月，无蛋白尿患者为10个月（p<0.001）。作为一个整体分析，蛋白尿与较短生存期之间的关联在肠道肿瘤、肺部肿瘤及其他部位肿瘤患者中具有统计学意义。未对骨髓瘤或泌尿系统肿瘤患者进行研究。在许多恶性肿瘤患者中，蛋白尿的存在可能与生存期显著缩短有关。
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