从沿海盐渍土真菌中发现有抗病毒潜力的紫檀烷酮类化合物。
Potential Antiviral Xanthones from a Coastal Saline Soil Fungus .
机构信息
College of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Laboratory of Flavor Chemistry, Beijing Laboratory for Food Quality and Safety, Beijing Technology and Business University, Beijing 100048, China.
出版信息
Mar Drugs. 2018 Nov 15;16(11):449. doi: 10.3390/md16110449.
Five new (⁻) and two known xanthones ( and ), one of the latter () obtained for the first time as a natural product, together with three known anthraquinones, questin, penipurdin A, and questinol, were isolated from the coastal saline soil-derived by application of an OSMAC (one strain many compounds) approach. Their structures were determined by interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, as well as comparison of these data with those of related known compounds. Antiviral activity of xanthones - was evaluated through the cytopathic effect (CPE) inhibition assay, and compound exhibited distinctly strong activity towards influenza virus (H1N1), herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) with IC values of 44.6, 21.4, and 76.7 μM, respectively, which indicated that it was worth to further investigate it as a potential lead compound. The preliminary structure-activity relationship of the xanthones is discussed.
从沿海盐土来源的 中，通过应用 OSMAC（一种菌株多种化合物）方法分离得到了五个新的（⁻）和两个已知的黄烷酮（和），其中一个是首次作为天然产物获得的，以及三种已知的蒽醌，questin、penipurdin A 和 questinol。通过核磁共振（NMR）和高分辨率电喷雾电离质谱（HRESIMS）数据的解释以及与相关已知化合物的数据比较，确定了它们的结构。通过细胞病变效应（CPE）抑制试验评估了黄烷酮 - 的抗病毒活性，化合物 对流感病毒（H1N1）、单纯疱疹病毒 1 型（HSV-1）和 2 型（HSV-2）表现出明显的强活性，IC 值分别为 44.6、21.4 和 76.7 μM，这表明它值得进一步研究作为一种有潜力的先导化合物。讨论了黄烷酮的初步结构-活性关系。
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