a Institute of Bioengineering and Nanotechnology, The Nanos , Singapore , Singapore.
Crit Rev Biotechnol. 2019 Nov;39(7):964-979. doi: 10.1080/07388551.2019.1641788. Epub 2019 Jul 22.
The prevention of infectious diseases is a global challenge where multidrug-resistant bacteria or "superbugs" pose a serious threat to worldwide public health. Microtopographic surfaces have attracted much attention as they represent a biomimetic and nontoxic surface antibacterial strategy to replace biocides. The antimicrobial effect of such natural and biomimetic surface nanostructures involves a physical approach which eradicates bacteria via the structural features of the surfaces without any release of biocides or chemicals. These recent developments present a significant proof-of-concept and a powerful tool in which cellular adhesion and death caused by a physical approach, can be controlled by the micro/nanotopology of such surfaces. This represents an innovative direction of development of clean, effective and nonresistant antimicrobial surfaces. The minireview will cover novel approaches for the construction of nanostructures on surfaces in order to create antimicrobial surface in an environmentally friendly, nontoxic manner.
传染病的预防是一个全球性的挑战，其中多药耐药菌或“超级细菌”对全球公共卫生构成严重威胁。微地形表面由于代表了一种仿生且无毒的表面抗菌策略，可以替代杀生物剂，因此受到了广泛关注。这种天然仿生表面纳米结构的抗菌效果涉及一种物理方法，通过表面的结构特征来消灭细菌，而不会释放任何杀生物剂或化学物质。这些最新进展提供了一个重要的概念验证，并提供了一个有力的工具，通过这种表面的微/纳米拓扑结构，可以控制由物理方法引起的细胞黏附和死亡。这代表了开发清洁、有效且不易产生耐药性的抗菌表面的一个创新方向。这篇综述将介绍在表面构建纳米结构的新方法，以便以环保、无毒的方式创建抗菌表面。
