School of Mechanical and Electrical Engineering, Henan Agricultural University, Zhengzhou 450002, China.
Molecules. 2024 Apr 23;29(9):1906. doi: 10.3390/molecules29091906.
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the need to combat bacterial infections with the use of radically different approaches. Taking lessons from the exciting properties of micro-/nano-natural-patterned surfaces, which can destroy cellular integrity, the construction of artificial surfaces to mimic natural functions provides new opportunities for the innovation and development of biomedicine. Due to the diversity of natural surfaces, functional surfaces inspired by natural surfaces have a wide range of applications in healthcare. Nature-inspired surface structures have emerged as an effective and durable strategy to prevent bacterial infection, opening a new way to alleviate the problem of bacterial drug resistance. The present situation of bactericidal and antifouling surfaces with natural and biomimetic micro-/nano-structures is briefly reviewed. In addition, these innovative nature-inspired methods are used to manufacture a variety of artificial surfaces to achieve extraordinary antibacterial properties. In particular, the physical antibacterial effect of nature-inspired surfaces and the functional mechanisms of chemical groups, small molecules, and ions are discussed, as well as the wide current and future applications of artificial biomimetic micro-/nano-surfaces. Current challenges and future development directions are also discussed at the end. In the future, controlling the use of micro-/nano-structures and their subsequent functions will lead to biomimetic surfaces offering great potential applications in biomedicine.
随着医疗保健水平的提高，细菌耐药性问题变得越来越普遍。令人担忧的是，抗生素的滥用导致细菌对多种药物的耐药性增加，而新抗生素的研发几乎停滞不前。这些挑战促使人们需要采用截然不同的方法来对抗细菌感染。从微纳天然图案表面令人兴奋的特性中吸取教训，这些表面可以破坏细胞完整性，通过模仿自然功能来构建人工表面为生物医学的创新和发展提供了新的机会。由于天然表面的多样性，受天然表面启发的功能表面在医疗保健中有广泛的应用。受自然启发的表面结构已成为预防细菌感染的有效且持久的策略，为缓解细菌耐药性问题开辟了新途径。本文简要综述了具有天然和仿生微纳结构的杀菌和抗污表面的现状。此外，还利用这些创新的受自然启发的方法来制造各种人工表面，以实现非凡的抗菌性能。特别讨论了受自然启发的表面的物理抗菌作用以及化学基团、小分子和离子的功能机制，以及人工仿生微纳表面的广泛的当前和未来应用。最后还讨论了当前的挑战和未来的发展方向。在未来，控制微纳结构及其后续功能的使用将导致仿生表面在生物医学领域具有巨大的潜在应用。
