Division of Periodontology, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Division of Periodontology, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA
Infect Immun. 2019 Sep 19;87(10). doi: 10.1128/IAI.00280-19. Print 2019 Oct.
is considered a keystone pathogen that contributes to the initiation and progression of periodontitis in humans. has also been detected in human placentas associated with adverse pregnancy outcomes. The spread of from the oral cavity to the reproductive tract thus represents a potential mechanism whereby periodontitis can lead to adverse pregnancy outcomes. In a murine model of pregnancy and oral infection with , C57BL/6J mice developed low fetal weight, whereas C57BL/6NCrl mice did not. Although C57BL/6NCrl mice harbor segmented filamentous bacteria that drive a Th17 response, fetal weight was independent of frequency of Th17 or Th1 in either substrain. Low fetal weight was instead correlated with increasing amounts of DNA in the placentas of the C57BL/6J dams. In contrast, fetal weight in C57BL/6NCrl mice was independent of in the placenta. Differences in genetics or microbiome that influence the ability of to colonize the placenta may drive differential fetal weight outcomes between C57BL/6J and C57BL/6NCrl mice and, potentially, between diverse human populations.
被认为是一种关键病原体，它有助于人类牙周炎的发生和发展。也已在与不良妊娠结局相关的人类胎盘组织中检测到。因此，从口腔传播到生殖道代表了牙周炎可能导致不良妊娠结局的潜在机制。在与牙周炎相关的口腔感染的妊娠和口腔感染的小鼠模型中，C57BL/6J 小鼠的胎儿体重较低，而 C57BL/6NCrl 小鼠则没有。尽管 C57BL/6NCrl 小鼠携带有驱动 Th17 反应的分段丝状细菌，但胎儿体重与两种亚系的 Th17 或 Th1 频率无关。相反，低胎儿体重与 C57BL/6J 母鼠胎盘内 数量的增加呈正相关。相比之下，C57BL/6NCrl 小鼠的胎儿体重与胎盘内的 无关。影响 定植胎盘能力的遗传或微生物组差异可能导致 C57BL/6J 和 C57BL/6NCrl 小鼠之间以及不同人群之间的胎儿体重结果存在差异。
