Lewis血型阴性癌症患者血清和唾液中CA19-9的存在情况。
The presence of CA19-9 in serum and saliva from Lewis blood-group negative cancer patients.
作者信息
Yazawa S, Asao T, Izawa H, Miyamoto Y, Matta K L
机构信息
Department of Legal Medicine, School of Medicine, Gunma University, Maebashi.
出版信息
Jpn J Cancer Res. 1988 Apr;79(4):538-43. doi: 10.1111/j.1349-7006.1988.tb01624.x.
Abstract
Eighteen cancer patients showed high levels of CA19-9 in sera, even though the blood-group phenotypes of their red blood cells were Le(a-b-). Seven of these patients (group I) were determined as Le(a-b-) from both red blood cells and saliva consistently, whereas eleven other patients (group II) secreted either Le(a) or Le(b) antigen in saliva and showed the expression of incompatible Lewis blood-group antigens. GDP-fucose: N-acetyl-glucosaminide alpha(1----4)-L-fucosyltransferase was demonstrated to be present in salivas from both group I and group II. These results suggest that a cancer-associated alteration of Lewis blood-group antigen expression occurs in cancer patients.
摘要
18名癌症患者血清中CA19-9水平较高，尽管其红细胞的血型表型为Le(a-b-)。其中7名患者（I组）红细胞和唾液均被一致确定为Le(a-b-)，而另外11名患者（II组）唾液中分泌Le(a)或Le(b)抗原，并表现出不相容的Lewis血型抗原表达。I组和II组唾液中均证实存在GDP-岩藻糖：N-乙酰葡糖胺α(1----4)-L-岩藻糖基转移酶。这些结果表明，癌症患者中发生了与癌症相关的Lewis血型抗原表达改变。
相似文献
1
The presence of CA19-9 in serum and saliva from Lewis blood-group negative cancer patients.Lewis血型阴性癌症患者血清和唾液中CA19-9的存在情况。
Jpn J Cancer Res. 1988 Apr;79(4):538-43. doi: 10.1111/j.1349-7006.1988.tb01624.x.
2
Loss of Lewis antigen expression on erythrocytes in some cancer patients with high serum CA19-9 levels.部分血清CA19-9水平较高的癌症患者红细胞上Lewis抗原表达缺失。
J Natl Cancer Inst. 1987 Dec;79(6):1261-8.
3
Genetic and enzymatic evidence for Lewis enzyme expression in Lewis-negative cancer patients.Lewis阴性癌症患者中Lewis酶表达的遗传学和酶学证据。
Cancer Res. 1995 Apr 1;55(7):1473-8.
4
alpha-L-Fucosyltransferases related to biosynthesis of blood group substances in human Saliva.与人类唾液中血型物质生物合成相关的α-L-岩藻糖基转移酶
J Immunogenet. 1980 Apr;7(2):137-48. doi: 10.1111/j.1744-313x.1980.tb00715.x.
5
Lewis antigen expression in benign and malignant tissues from RBC Le(a-b-) cancer patients.红细胞Le(a-b-)癌症患者良性和恶性组织中的Lewis抗原表达
Br J Haematol. 1991 Nov;79(3):493-9. doi: 10.1111/j.1365-2141.1991.tb08061.x.
6
Elevated activities of blood group Le gene dependent alpha(1----3)-L-fucosyltransferase in human saliva of Lewis negative patients with epithelial ovarian cancer.
Cancer Lett. 1986 Aug;32(2):165-9. doi: 10.1016/0304-3835(86)90115-1.
7
Expression of blood group-related antigens in normal and malignant pancreatic tissue correlated with genotype of the patient defined by saliva glycoprotein.正常和恶性胰腺组织中血型相关抗原的表达与由唾液糖蛋白定义的患者基因型相关。
Cancer. 1993 Jan 1;71(1):71-81. doi: 10.1002/1097-0142(19930101)71:1<71::aid-cncr2820710113>3.0.co;2-4.
8
alpha1,4-Fucosyltransferase activity in human serum and saliva.人血清和唾液中的α1,4-岩藻糖基转移酶活性
Arch Biochem Biophys. 1996 Nov 1;335(1):109-17. doi: 10.1006/abbi.1996.0487.
9
A Bombay individual lacking H and Le antigens but expressing normal levels of alpha-2- and alpha-4-fucosyltransferases.一名孟买血型个体，缺乏H和Le抗原，但α-2-岩藻糖基转移酶和α-4-岩藻糖基转移酶水平正常。
Transfusion. 1995 Sep;35(9):773-6. doi: 10.1046/j.1537-2995.1995.35996029164.x.
10
Investigation of unexpected serum CA19-9 elevation in Lewis-negative cancer patients.Lewis 阴性癌症患者血清 CA19-9 升高的意外调查。
Ann Clin Biochem. 2012 May;49(Pt 3):266-72. doi: 10.1258/acb.2011.011213. Epub 2012 Apr 5.
引用本文的文献
1
α-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers.具有高度岩藻糖基化聚糖的α-酸性糖蛋白作为肝胆胰癌早期检测的潜在诊断标志物
Diagnostics (Basel). 2024 Dec 27;15(1):40. doi: 10.3390/diagnostics15010040.
2
Preoperative CA19‑9 level and dual time point FDG‑PET/CT as strong biological indicators of borderline resectability in pancreatic cancer: A retrospective study.术前CA19-9水平和双时间点FDG-PET/CT作为胰腺癌边界可切除性的强生物学指标：一项回顾性研究
Oncol Lett. 2024 Apr 23;27(6):279. doi: 10.3892/ol.2024.14412. eCollection 2024 Jun.
3
Fucosylated Glycans in α1-Acid Glycoprotein for Monitoring Treatment Outcomes and Prognosis of Cancer Patients.α1-酸性糖蛋白中的岩藻糖基化聚糖用于监测癌症患者的治疗结果和预后
PLoS One. 2016 Jun 13;11(6):e0156277. doi: 10.1371/journal.pone.0156277. eCollection 2016.
4
Associated expression of α2,3sialylated type 2 chain structures with lymph node metastasis in distal colorectal cancer.α2,3 唾液酸化的 II 型链结构与远端结直肠癌淋巴结转移的相关性表达。
Surg Today. 2013 Feb;43(2):155-62. doi: 10.1007/s00595-012-0141-9. Epub 2012 Mar 8.
5
Aberrant alpha 1-->2fucosyltransferases found in human colorectal carcinoma involved in the accumulation of Leb and Y antigens in colorectal tumors.在人类结直肠癌中发现的异常α1→2岩藻糖基转移酶与结直肠肿瘤中Leb和Y抗原的积累有关。
Jpn J Cancer Res. 1993 Sep;84(9):989-95. doi: 10.1111/j.1349-7006.1993.tb00190.x.
6
Development and characterization of a novel anti-fucosylated antigen monoclonal antibody YB-2 and its usefulness in the immunohistochemical diagnosis of colorectal cancer.新型抗岩藻糖基化抗原单克隆抗体YB-2的研制、特性及其在结直肠癌免疫组织化学诊断中的应用
Jpn J Cancer Res. 1993 Jun;84(6):641-8. doi: 10.1111/j.1349-7006.1993.tb02024.x.
7
Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.胰腺癌患者中与癌症相关的肿瘤标志物CA 19-9和CA-50，特别提及Lewis血型状态
Br J Cancer. 1990 Jul;62(1):118-21. doi: 10.1038/bjc.1990.241.
8
Frequency and mechanism of Lewis antigen expression in human urinary bladder and colon carcinoma patients.人类膀胱癌和结肠癌患者中Lewis抗原表达的频率及机制
Br J Cancer. 1991 Apr;63(4):583-6. doi: 10.1038/bjc.1991.135.
9
Elevated serum levels of Dupan-2 in pancreatic cancer patients negative for Lewis blood group phenotype.Lewis血型表型阴性的胰腺癌患者血清中Dupan-2水平升高。
Br J Cancer. 1991 Nov;64(5):899-902. doi: 10.1038/bjc.1991.422.
本文引用的文献
1
Transformation of the Lewis groups of human red cells.人红细胞Lewis血型基团的转变
Nature. 1955 Jul 23;176(4473):172. doi: 10.1038/176172a0.
2
Lewis phenotype of erythrocytes and Leb-active glycolipid in serum of pregnant women.孕妇血清中红细胞的Lewis表型及Leb活性糖脂
Vox Sang. 1981 Jan;40(1):27-33. doi: 10.1111/j.1423-0410.1981.tb00665.x.
3
4
alpha-L-Fucosyltransferases related to biosynthesis of blood group substances in human Saliva.与人类唾液中血型物质生物合成相关的α-L-岩藻糖基转移酶
J Immunogenet. 1980 Apr;7(2):137-48. doi: 10.1111/j.1744-313x.1980.tb00715.x.
5
Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.针对单克隆抗体定义的肿瘤标志物CA 19-9的放射免疫分析。
Clin Chem. 1983 Mar;29(3):549-52.
6
Immunochemical properties of human plasma alpha 1 leads to 2 fucosyltransferase specified by blood group H-gene.
J Immunogenet. 1983 Oct;10(5):349-60. doi: 10.1111/j.1744-313x.1983.tb00347.x.
7
8
Lewis blood-type may affect the incidence of gastrointestinal cancer.
Lancet. 1982 Jun 12;1(8285):1332-3. doi: 10.1016/s0140-6736(82)92402-3.
9
Glycosphingolipids with Lewis blood group activity: uptake by human erythrocytes.具有Lewis血型活性的糖鞘脂：人红细胞的摄取
Science. 1969 May 2;164(3879):553-5. doi: 10.1126/science.164.3879.553.
10
Enzymes from human gastric mucosa conferring blood-group A and B specificities upon erythrocytes.来自人胃黏膜的酶赋予红细胞A和B血型特异性。
Eur J Biochem. 1970 Dec;17(2):218-22. doi: 10.1111/j.1432-1033.1970.tb01156.x.
Zotero 插件