Faculty of Health Sciences, Department of Clinical Nursing, Wroclaw Medical University, Wroclaw, Poland.
Student Scientific Societies of Clinical Nursing, Public Health Department, Wroclaw Medical University, Wroclaw, Poland.
Scand J Caring Sci. 2020 Jun;34(2):380-389. doi: 10.1111/scs.12739. Epub 2019 Jul 23.
Acute lymphoblastic leukaemia (ALL) is one of the most common neoplasms in children, that is. 3,000 new cases are diagnosed in the USA each year. The assessment of the quality of life (QoL) by the patient is the important indicator of the effects of treatment by the means of physical, psychical and social functioning.
The aim of the study was to evaluate the QoL of children treated for ALL and the stress levels of their parents. Additionally, the impact of the most common symptoms on perceived QoL was analysed.
Seventy-four patients with ALL (mean age 9.03) were enrolled in the study. The questionnaire of Paediatric Quality of Life (PedsQL) and the medical records as the source of the socio-clinical data were applied in this study.
In QoL assessment, the social functioning reached the highest score (67.57 ± 21.33), and physical functioning - the lowest score (51.1 ± 25.59). The analysis of the symptoms showed that the most intensive were stress (7.19 ± 2.71), fatigue and weakness (5.19 ± 2.76). In Spearman's rank correlation analysis the depressed mood, fatigue and weakness were significant negative predictors influencing QoL in all the domains of PedsQoL. In the linear regression analysis only the depressed mood was the significant independent determinant of the decreased QoL in the majority of the domains of PedsQoL, respectively: the general QoL (β = -0.314; p = 0.002); psychosocial functioning (β = -3.44; p < 0.01); role functioning (β = -3.18; p = 0.004); social functioning (β = -3.5; p = 0.007) and emotional functioning (β = -3.012; p = 0.002).
Quality of life of children with ALL is decreased and of the lowest value in the range of physical health. The factors negatively influencing the QoL are depressed mood, fatigue and weakness. The significant independent determinant of the decreased QoL is children's depressed mood.
急性淋巴细胞白血病（ALL）是儿童中最常见的肿瘤之一。 美国每年诊断出 3000 例新病例。患者对生活质量（QoL）的评估是治疗对身体、心理和社会功能影响的重要指标。
本研究旨在评估接受 ALL 治疗的儿童的生活质量（QoL）和其父母的压力水平，并分析常见症状对感知 QoL 的影响。
本研究纳入了 74 例 ALL 患儿（平均年龄 9.03 岁）。采用儿科生活质量问卷（PedsQL）和病历作为社会临床数据的来源进行研究。
在 QoL 评估中，社会功能得分最高（67.57±21.33），身体功能得分最低（51.1±25.59）。对症状的分析表明，压力最大（7.19±2.71），疲劳和虚弱（5.19±2.76）。在 Spearman 秩相关分析中，抑郁情绪、疲劳和虚弱是所有 PedsQoL 领域中影响 QoL 的显著负性预测因素。在线性回归分析中，只有抑郁情绪是大多数 PedsQoL 领域中 QoL 下降的显著独立决定因素，分别为：一般 QoL（β=-0.314；p=0.002）；心理社会功能（β=-3.44；p<0.01）；角色功能（β=-3.18；p=0.004）；社会功能（β=-3.5；p=0.007）和情绪功能（β=-3.012；p=0.002）。
ALL 患儿的生活质量下降，身体健康状况最差。影响 QoL 的负性因素是抑郁情绪、疲劳和虚弱。儿童抑郁情绪是 QoL 下降的显著独立决定因素。
