State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Chemistry. 2019 Oct 17;25(58):13429-13435. doi: 10.1002/chem.201903322. Epub 2019 Sep 13.
Spatiotemporally coupled tumor phototheranostic platforms offer a flexible and precise system that takes the biological interaction between tumors and photoactive agents into consideration for optimizing treatment, which is highly consistent with precision medicine. However, the fabrication of monocomponent-based photoactive agents applicable to multifold imaging techniques and multiple therapies in a facile way remains challenging. In this study, we developed simple phthalocyanine-peptide (PF) conjugate-based monocomponent nanoparticles with spatiotemporally coupled photoactivity for adaptive tumor theranostics. The self-assembled PF nanoparticles possess well-defined spherical nanostructures and excellent colloidal stability along with supramolecular photothermal effects. Importantly, the PF nanoparticles showed switchable photoactivity triggered by their interactions with the cell membrane, which enables an adaptive transformation from photothermal therapy (PTT) and photoacoustic imaging (PAI) to photodynamic therapy (PDT) and corresponding fluorescence imaging (FI). Theranostic modalities are integrated in a spatiotemporally coupled manner, providing a facile, biocompatible and effective route for localized tumor phototherapy. This study offers a flexible and versatile strategy to integrate multiple theranostic modalities into a single component so that it can realize its full potential and thereby amplify its therapeutic efficacy, creating promising opportunities for the design of theranostics and further highlighting their clinical prospects to the diagnosis and treatment of cancers.
时空耦合同步肿瘤光热诊疗平台提供了一种灵活、精确的系统，考虑到肿瘤与光活性试剂之间的生物相互作用，以优化治疗效果，这与精准医疗高度一致。然而，以简单的方式制备适用于多种成像技术和多种治疗方法的基于单一组分的光活性试剂仍然具有挑战性。在本研究中，我们开发了基于简单酞菁-肽（PF）偶联物的单一组分纳米粒子，具有时空耦合同步光活性，可用于适应性肿瘤治疗。自组装的 PF 纳米粒子具有良好定义的球形纳米结构和优异的胶体稳定性以及超分子光热效应。重要的是，PF 纳米粒子表现出可切换的光活性，这是由它们与细胞膜的相互作用触发的，这使得从光热疗法（PTT）和光声成像（PAI）到光动力疗法（PDT）和相应的荧光成像（FI）的自适应转换成为可能。治疗模式以时空耦合同步的方式集成，为局部肿瘤光疗提供了一种简便、生物相容且有效的途径。这项研究提供了一种灵活、通用的策略，将多种治疗模式集成到单个组件中，从而充分发挥其潜力，增强治疗效果，为治疗和诊断癌症的治疗提供了有前景的机会。
