核壳结构金纳米棒@层状双氢氧化物纳米材料具有高效光热转换性能及其在抗菌和肿瘤治疗中的应用。
Core-Shell Gold Nanorod@Layered Double Hydroxide Nanomaterial with Highly Efficient Photothermal Conversion and Its Application in Antibacterial and Tumor Therapy.
机构信息
State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry , Beijing University of Chemical Technology , North Third Ring Road 15 , Chaoyang District, Beijing 100029 , China.
Department of Hepatobiliary Surgery, Department of Gastroenterology , China-Japan Friendship Hospital , 2 Yinghuayuan Dongjie , Beijing 100029 , China.
出版信息
ACS Appl Mater Interfaces. 2019 Aug 21;11(33):29630-29640. doi: 10.1021/acsami.9b10373. Epub 2019 Aug 6.
Photothermal conversion efficiency (η) of gold nanorods (GNRs) can be tuned by enlarging the aspect ratio and forming the core-shell structure. Herein, an easy synthesis method is developed to construct the core-shell GNR@LDH nanostructure with GNRs and layered double hydroxides (LDHs). The interaction between Au and LDHs results some electron deficiency on the surface of Au and the more electrons induce more thermal energy conversion. The η value of GNR@LDH can reach up to 60% under the 808 nm laser irradiation, which is a significant enhanced conversion efficiency compared with the reported GNR-based photothermal therapy materials. CTAB (cetyltrimethyl ammonium bromide) can be replaced totally during the synthesis process, and GNRs maintain a good dispersion in LDHs. This core-shell composite GNR@LDH can be applied in photothermal, antibacterial, tumor therapy and biological imaging with low dosage and nontoxicity.
金纳米棒（GNRs）的光热转换效率（η）可以通过增大纵横比和形成核壳结构来调节。在此，开发了一种简便的合成方法，用于构建具有金纳米棒（GNRs）和层状双氢氧化物（LDHs）的核壳 GNR@LDH 纳米结构。Au 与 LDHs 的相互作用导致 Au 表面出现电子缺失，而更多的电子则会引发更多的热能转换。在 808nm 激光照射下，GNR@LDH 的η值可达 60%，与已报道的基于 GNR 的光热治疗材料相比，这是一个显著提高的转换效率。在合成过程中可以完全取代 CTAB（十六烷基三甲基溴化铵），并且 GNRs 在 LDHs 中保持良好的分散性。这种核壳复合 GNR@LDH 可以在低剂量和无毒的情况下应用于光热、抗菌、肿瘤治疗和生物成像。
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