Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, China.
Stroke Vasc Neurol. 2019 May 10;4(2):71-74. doi: 10.1136/svn-2018-000196. eCollection 2019 Jul.
Ischaemic stroke can induce rapid activation of microglia. As the resident immune cells of the central nervous system, microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue. The activation of microglia after ischaemia involves several stereotypical events including morphological transformation, proliferation and polarisation. Studies using confocal or two-photon imaging techniques have revealed that the degree of microglial activation is correlated with the degree of ischaemia. Activated microglia display diverse polarisation phenotypes. It remains largely unclear regarding whether activated microglia are beneficial or detrimental to poststroke recovery. This mini-review focuses on the morphological and functional aspects of microglial activation, with particular attention to progress in two-photon imaging studies.
缺血性中风可诱导小胶质细胞的快速激活。小胶质细胞作为中枢神经系统的固有免疫细胞，被认为在神经炎症和缺血组织的病理进展中起核心作用。缺血后小胶质细胞的激活涉及几个典型事件，包括形态转化、增殖和极化。使用共聚焦或双光子成像技术的研究表明，小胶质细胞的激活程度与缺血程度相关。激活的小胶质细胞表现出不同的极化表型。关于激活的小胶质细胞对中风后恢复是有益还是有害，目前还不完全清楚。本综述重点介绍小胶质细胞激活的形态和功能方面，特别关注双光子成像研究的进展。
