Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Biol Trace Elem Res. 2020 May;195(1):20-26. doi: 10.1007/s12011-019-01830-3. Epub 2019 Jul 23.
Kidney stones, a painful and costly disease, have become a public health problem worldwide. The aim of this study was to evaluate the association between serum magnesium levels and the prevalence of kidney stones in a large population context. This study was conducted in Xiangya Hospital, Central South University in Changsha, Hunan, China, between October 2013 and December 2015. A total of 6228 subjects aged ≥ 18 years old were included. Kidney stones were diagnosed by (1) direct visualisation of stone(s) on the abdominal ultrasound examination, and (2) presence of stone(s) with a diameter ≥ 4 mm. The chemiluminescence method was used to measure the serum magnesium concentration. The association between serum magnesium and the prevalence of kidney stones was evaluated using logistic and spline regression in a cross-sectional study. The prevalence of kidney stones was 6.1% (7.5% in men and 4.2% in women). Compared with the lowest quartile, the crude odds ratio for kidney stones was 0.62 (95% CI 0.46-0.85) for the highest quartile of serum magnesium, and there was an inverse dose-response relationship (P for trend = 0.038). Similar results were observed for men and women separately. The findings were not materially altered by adjustment for potential confounders. In conclusion, subjects with relatively lower levels of serum magnesium, even though within the normal range, were subject to a higher prevalence of kidney stones in a dose-response relationship manner, indicating that magnesium may play a certain role in the prevention or treatment of kidney stones.
肾结石是一种痛苦且昂贵的疾病，已成为全球范围内的公共卫生问题。本研究旨在评估人群血清镁水平与肾结石患病率之间的关系。本研究于 2013 年 10 月至 2015 年 12 月在中南大学湘雅医院进行。共纳入 6228 名年龄≥18 岁的受试者。肾结石的诊断依据为：（1）腹部超声检查直接观察到结石；（2）结石直径≥4mm。采用化学发光法测量血清镁浓度。在横断面研究中，采用逻辑回归和样条回归评估血清镁与肾结石患病率之间的关系。肾结石的患病率为 6.1%（男性为 7.5%，女性为 4.2%）。与血清镁最低四分位相比，血清镁最高四分位的肾结石粗比值比为 0.62（95%CI 0.46-0.85），呈负相关趋势（P 趋势=0.038）。男性和女性分别观察到相似的结果。调整潜在混杂因素后，结果无明显变化。结论：即使在正常范围内，血清镁水平相对较低的受试者，其肾结石患病率呈剂量反应关系升高，表明镁可能在肾结石的预防或治疗中发挥一定作用。
