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肝和胰头部同时出现细粒棘球蚴病的罕见病例:病例报告分析及文献复习。

A rare case of the simultaneous location of Echinococcus multilocularis in the liver and the head of the pancreas: case report analysis and review of literature.

机构信息

Department of Laboratory Medicine Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Clinic of Oncological and General Surgery, University Clinical Hospital in Olsztyn, Olsztyn, Poland.

出版信息

BMC Infect Dis. 2019 Jul 24;19(1):661. doi: 10.1186/s12879-019-4274-y.

Abstract

BACKGROUND

Echinococcosis multilocularis (Hydatid Disease - HD) is a zoonotic disease caused by the larval form of Echinococcus multilocularis (EM). The main sites for this zoonosis are the Middle East, China, India, Alaska, and Siberia. It is rather rare in Europe. In Poland, the Warmian-Masurian Province is the endemic region for Echinococcus multilocularis. The clinical manifestation of the disease is dependent on the location, the size of the cyst and the development stage of the parasite. Considering the uncommon character of echinococcosis in Central Europe, especially such located in the areas outside the liver and lungs, the authors would like to present a case of coexistence in one patient of two EM foci in the liver and the head of the pancreas.

CASE PRESENTATION

We present a clinical case of a 32-year-old man who was diagnosed with a cystic lesion with septa and calcification in the sixth segment of the liver and a suspicious change in the head of the pancreas. ELISA Em 2 plus test was positive, Western Blot method - the P-5 pattern showed an image that is characteristic of an EM infection. The sixth liver segment with a tumour and a tumour from the head of pancreas were excised by means of laparotomy. On the 6th day after the surgery the patient was discharged from hospital without complications and in good condition. Currently, he is under the control of a parasitic and zoonotic clinic. He takes an 800 mg daily dosage of Albendazole.

CONCLUSIONS

The presented clinical case shows that if we have a patient with cystic / tumour change in the pancreas and positive immunological tests, CT and MRI of the abdominal cavity are usually sufficient in order to fully diagnose and to qualify such a person for surgery. The most effective treatment is surgical treatment supplemented with pre- and postsurgical treatment with Albendazole.

摘要

背景

泡型包虫病(包虫病 - HD)是一种由细粒棘球绦虫(EM)幼虫引起的人畜共患疾病。这种人畜共患病的主要发生地是中东、中国、印度、阿拉斯加和西伯利亚。在欧洲相当罕见。在波兰,瓦尔米亚-马祖里省是细粒棘球绦虫的流行地区。该疾病的临床表现取决于位置、囊肿的大小和寄生虫的发育阶段。考虑到中欧棘球蚴病的罕见性,特别是位于肝外和肺外的棘球蚴病,作者希望提出一例同时存在于肝脏和胰腺头部的两个 EM 病灶的病例。

病例介绍

我们报告了一名 32 岁男性的临床病例,他被诊断为肝脏第六段有一个带分隔和钙化的囊性病变,胰腺头部有可疑变化。ELISA Em 2 plus 试验呈阳性,Western Blot 方法 - P-5 模式显示出与 EM 感染特征相符的图像。通过剖腹手术切除了第六肝段的肿瘤和胰腺头部的肿瘤。手术后第 6 天,患者无并发症出院,身体状况良好。目前,他在寄生虫和人畜共患病诊所接受控制。他每天服用 800 毫克的阿苯达唑。

结论

所介绍的临床病例表明,如果我们有胰腺囊性/肿瘤变化且免疫测试呈阳性的患者,通常情况下腹部 CT 和 MRI 足以进行全面诊断,并为该患者进行手术资格鉴定。最有效的治疗方法是手术治疗,并辅以阿苯达唑的术前和术后治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1729/6657101/85ab6153a034/12879_2019_4274_Fig1_HTML.jpg

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