Ghorbani-Choboghlo Hassan, Nikaein Donya, Khosravi Ali-Reza, Rahmani Reza, Farahnejad Zohreh
Department of Medical Mycology, AJA University of Medical Sciences, Tehran, Iran.
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Iran J Microbiol. 2019 Apr;11(2):160-165.
Probiotics are live microorganisms that, when administered in an adequate amount, confer a health benefit on the host through the gut. is a widespread yeast found in nature. This microorganism has been used as a probiotic agent in recent years. In this study, the effect of microencapsulation on survival rate of in the simulated gastrointestinal tract medium and the impact of microencapsulated on some serum biochemical factors in a rat model was evaluated.
30 male wistar rats were divided into three groups (control, rats receiving microencapsulated , and rats receiving alone). The probiotic was gavaged at a dosage of 2 gr/kg BW for 8 weeks. Blood was collected from rats at the end of the treatment period and biochemical factors were measured using Mancompany kits.
The results showed a significant increase in viability of microencapsulated in comparison with free (p<0.05). Weight of rats in probiotic treated groups was significantly higher in comparison with the control group (p<0.05). Moreover, probiotic treatment reduced mean levels of triglycerides, cholesterol, free blood sugar and liver enzymes in rats.
Microencapsulation could increase the survival rate of yeast probiotics in the gastrointestinal tract; however, more studies are needed for better understanding of the exact effect of microencapsulation on probiotics' function.
益生菌是一类活的微生物，当给予足够数量时，可通过肠道为宿主带来健康益处。酿酒酵母是一种在自然界广泛存在的酵母。近年来，这种微生物已被用作益生菌制剂。在本研究中，评估了微囊化对酿酒酵母在模拟胃肠道介质中的存活率的影响以及微囊化酿酒酵母对大鼠模型中某些血清生化因子的影响。
将30只雄性Wistar大鼠分为三组（对照组、接受微囊化酿酒酵母的大鼠组和仅接受酿酒酵母的大鼠组）。以2克/千克体重的剂量对大鼠进行灌胃益生菌，持续8周。在治疗期结束时从大鼠采集血液，并使用曼康公司的试剂盒测量生化因子。
结果显示，与游离酿酒酵母相比，微囊化酿酒酵母的存活率显著提高（p<0.05）。益生菌治疗组大鼠的体重与对照组相比显著更高（p<0.05）。此外，益生菌治疗降低了大鼠甘油三酯、胆固醇、空腹血糖和肝酶的平均水平。
微囊化可提高酵母益生菌在胃肠道中的存活率；然而，需要更多研究以更好地了解微囊化对益生菌功能的确切影响。
