Godara Satish, Arora Sandeep, Dabas Rajeshwari, Arora Gulhima, Renganathan Gopi, Choudhary Richa
Department of Dermatology, Military Hospital, Secunderabad, Telangana, India.
Department of Dermatology, Command Hospital Air Force, Bengaluru, Karnataka, India.
Indian Dermatol Online J. 2020 Sep 19;11(6):930-936. doi: 10.4103/idoj.IDOJ_174_20. eCollection 2020 Nov-Dec.
Surgical correction of scars may not be an ideal solution in all cases and hence it is desirable to have a nonsurgical option available. Autologous platelet-rich plasma (PRP) and fractional carbon dioxide laser (FCL) offer an alternative treatment modality.
To compare the efficacy and safety of FCL and intradermal PRP with FCL in the management of postburn and posttraumatic scars.
A prospective, randomized, observer-blinded, comparative study was conducted at a hospital skin centre from Oct 2016 to Sep 2018.
A total of 67 patients with scars were randomly divided into two groups; Group I was treated with four sessions of monthly FCL and Group II was treated with four sessions of PRP and FCL. The patients were assessed using the Patient and Observer Scar Assessment Scale (POSAS) at baseline and 4 weeks after each session.
For continuous variables, the summary statistics of mean ± standard deviation was used; for categorical data, number and percentage were used. Chi-square (χ2) test was used for association between two categorical variables. value <0.05 was considered to be statistically significant.
Thirty cases in each group completed the study. There was a significant improvement in the total score of POSAS (p < 0.001) in both groups, but the final difference between the two groups was not statistically significant (p = 0.793 and = 0.278, respectively).
Fractional CO2 laser causes significant improvement in scar appearance. PRP in combination with FCL offers no additional advantage.
在所有情况下，手术矫正疤痕可能并非理想的解决方案，因此需要有非手术选择。自体富血小板血浆（PRP）和分次二氧化碳激光（FCL）提供了一种替代治疗方式。
比较FCL以及皮内注射PRP联合FCL治疗烧伤和创伤后疤痕的疗效和安全性。
2016年10月至2018年9月在一家医院皮肤中心进行了一项前瞻性、随机、观察者盲法的对照研究。
总共67例疤痕患者被随机分为两组；第一组接受每月一次、共四次的FCL治疗，第二组接受四次PRP联合FCL治疗。在基线时以及每次治疗后4周，使用患者和观察者疤痕评估量表（POSAS）对患者进行评估。
对于连续变量，使用均值±标准差的汇总统计量；对于分类数据，使用数量和百分比。卡方（χ2）检验用于两个分类变量之间的关联性分析。p值<0.05被认为具有统计学意义。
每组各有30例患者完成研究。两组的POSAS总分均有显著改善（p < 0.001），但两组之间的最终差异无统计学意义（分别为p = 0.793和 = 0.278）。
分次二氧化碳激光可显著改善疤痕外观。PRP联合FCL并无额外优势。
