长期风力涡轮机噪声暴露与丹麦护士队列中心律失常事件的风险。

Long-term wind turbine noise exposure and the risk of incident atrial fibrillation in the Danish Nurse cohort.

机构信息

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

出版信息

Environ Int. 2019 Sep;130:104915. doi: 10.1016/j.envint.2019.104915. Epub 2019 Jul 22.

DOI:10.1016/j.envint.2019.104915

PMID:31344645

Abstract

BACKGROUND

The potential health effects related to wind turbine noise (WTN) have received increased focus during the past decades, but evidence is sparse. We examined the association between long-term exposure to wind turbine noise and incidence of atrial fibrillation (AF).

METHODS

First ever hospital admission of AF amongst 28,731 female nurses in the Danish Nurse Cohort were identified in the Danish National Patient register until ultimo 2013. WTN levels at residential addresses between 1982 and 2013 were estimated using the Nord2000 noise propagation model, as the annual means of L L L and L at the most exposed façade. Time-varying Cox proportional hazard regression models were used to examine the association between the 11-, 5- and 1-year rolling means of WTN levels and AF incidence.

RESULTS

1430 nurses developed AF by end of follow-up in 2013. Mean (standard deviation) baseline residential noise levels amongst exposed nurses were 26.3 (6.7) dB and slightly higher in those who developed AF (27.3 (7.31) dB), than those who didn't (26.2 (6.6)). We observed a 30% statistically significant increased risk (95% CI: 1.05-1.61) of AF amongst nurses exposed to long-term (11-year running mean) WTN levels ≥20 dB(A) at night compared to nurses exposed to levels <20 dB(A). Similar effects were observed with day (HR 1.25; 95% CI: 1.01-1.54), and evening (HR 1.25; 95% CI: 1.01-1.54) noise levels.

CONCLUSIONS

We found suggestive evidence of an association between long-term exposure to WTN and AF amongst female nurses. However, interpretation should be cautious as exposure levels were low.

摘要

背景

在过去几十年中，与风力涡轮机噪声（WTN）相关的潜在健康影响受到了越来越多的关注，但证据仍然很少。我们研究了长期暴露于风力涡轮机噪声与心房颤动（AF）发病之间的关系。

方法

在丹麦护士队列中，28731 名女性护士首次在丹麦国家患者登记处登记为 AF 住院患者，直至 2013 年底。使用 Nord2000 噪声传播模型估算 1982 年至 2013 年期间居住地址的 WTN 水平，作为最暴露面的 L L L 和 L 的年平均值。使用时变 Cox 比例风险回归模型来检查 WTN 水平的 11 年、5 年和 1 年滚动平均值与 AF 发病率之间的关系。

结果

在 2013 年底的随访结束时，有 1430 名护士发生了 AF。暴露于 WTN 的护士的基线居住噪声水平的平均值（标准差）为 26.3（6.7）dB，略高于发生 AF 的护士（27.3（7.31）dB），而未发生 AF 的护士则为 26.2（6.6）dB。我们观察到，与暴露于 WTN 水平<20dB(A)的护士相比，长期（11 年滚动平均值）夜间 WTN 水平≥20dB(A)的护士发生 AF 的风险增加了 30%（95%CI：1.05-1.61）。白天（HR 1.25；95%CI：1.01-1.54）和傍晚（HR 1.25；95%CI：1.01-1.54）噪声水平也观察到类似的影响。