Section of Environmental Health Department of Public Health University of Copenhagen Denmark.
Department of Growth and Reproduction, Rigshospitalet University of Copenhagen Denmark.
J Am Heart Assoc. 2019 Jul 16;8(14):e013157. doi: 10.1161/JAHA.119.013157.
Background Epidemiological studies suggest that road traffic noise increases the risk of stroke. Similar effects may be expected from wind turbine noise (WTN) exposure, but epidemiological evidence is lacking. The present study investigated the association between long-term exposure to WTN and the risk for stroke. Methods and Results First-ever stroke in 28 731 female nurses in the Danish Nurse Cohort was identified in the Danish National Patient register until the end of 2013. WTN, traffic noise, and air pollution exposures were estimated for all historic and present residential addresses between 1982 and 2013. Time-varying Cox proportional hazard regression was used to examine the associations between the 11-, 5-, and 1-year rolling means of WTN levels and stroke incidence. Of 23 912 nurses free of stroke at the cohort baseline, 1097 nurses developed stroke by the end of follow-up. At the cohort baseline, 10.3% of nurses were exposed to WTN (≥1 turbine within a 6000-meter radius of the residence) and 13.3% in 2013. Mean baseline residential noise levels among exposed nurses were 26.3 dB(A). No association between long-term WTN exposure and stroke incidence was found. The adjusted hazard ratios and 95% CIs for the 11-, 5-, and 1-year running mean residential WTN exposures preceding stroke diagnosis, comparing nurses with residential WTN levels above and below 20 dB(A) were 1.09 (0.90-1.31), 1.08 (0.89-1.31) and 1.08 (0.89-1.32), respectively. Conclusions This comprehensive cohort study lends no support to an association between long-term WTN exposure and stroke risk.
流行病学研究表明，道路交通噪声会增加中风的风险。类似的影响可能来自风力涡轮机噪声（WTN）暴露，但缺乏流行病学证据。本研究调查了长期暴露于 WTN 与中风风险之间的关系。
在丹麦护士队列中，28731 名女性护士首次发生中风，在丹麦国家患者登记处，直到 2013 年底。在 1982 年至 2013 年期间，为所有历史和当前居住地址估算了 WTN、交通噪声和空气污染暴露。使用时变 Cox 比例风险回归来检查 WTN 水平的 11 年、5 年和 1 年滚动平均值与中风发病率之间的关联。在队列基线时，23912 名无中风的护士中，有 1097 名在随访结束时发生中风。在队列基线时，10.3%的护士暴露于 WTN（居住半径 6000 米范围内有 1 个以上涡轮机），而 2013 年则为 13.3%。暴露护士的基线居住噪声水平平均值为 26.3dB(A)。长期 WTN 暴露与中风发病率之间没有关联。在比较诊断前 11 年、5 年和 1 年的住宅 WTN 暴露的风险比和 95%置信区间，对于住宅 WTN 水平高于和低于 20dB(A)的护士分别为 1.09（0.90-1.31）、1.08（0.89-1.31）和 1.08（0.89-1.32）。
这项全面的队列研究没有支持长期 WTN 暴露与中风风险之间的关联。
