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长期暴露于风力涡轮机噪声对睡眠药物和抗抑郁药赎回的影响:一项全国性队列研究。

Impact of Long-Term Exposure to Wind Turbine Noise on Redemption of Sleep Medication and Antidepressants: A Nationwide Cohort Study.

机构信息

1 Diet, Genes and Environment, Danish Cancer Society Research Center , Copenhagen, Denmark.

2 Department of Environmental Science, Aarhus University , Roskilde, Denmark.

出版信息

Environ Health Perspect. 2019 Mar;127(3):37005. doi: 10.1289/EHP3909.

DOI:10.1289/EHP3909
PMID:30864815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6768316/
Abstract

BACKGROUND

Noise from wind turbines (WTs) is associated with annoyance and, potentially, sleep disturbances.

OBJECTIVES

Our objective was to investigate whether long-term WT noise (WTN) exposure is associated with the redemption of prescriptions for sleep medication and antidepressants.

METHODS

For all Danish dwellings within a radius of [Formula: see text] heights and for 25% of randomly selected dwellings within a radius of [Formula: see text] heights, we estimated nighttime outdoor and low-frequency (LF) indoor WTN, using information on WT type and simulated hourly wind. During follow-up from 1996 to 2013, 68,696 adults redeemed sleep medication and 82,373 redeemed antidepressants, from eligible populations of 583,968 and 584,891, respectively. We used Poisson regression with adjustment for individual and area-level covariates.

RESULTS

Five-year mean outdoor nighttime WTN of [Formula: see text] was associated with a hazard ratio (HR) = 1.14 [95% confidence interval (CI]: 0.98, 1.33) for sleep medication and HR = 1.17 (95% CI: 1.01, 1.35) for antidepressants (compared with exposure to WTN of [Formula: see text]). We found no overall association with indoor nighttime LF WTN. In age-stratified analyses, the association with outdoor nighttime WTN was strongest among persons [Formula: see text] of age, with HRs (95% CIs) for the highest exposure group ([Formula: see text]) of 1.68 (1.27, 2.21) for sleep medication and 1.23 (0.90, 1.69) for antidepressants. For indoor nighttime LF WTN, the HRs (95% CIs) among persons [Formula: see text] of age exposed to [Formula: see text] were 1.37 (0.81, 2.31) for sleep medication and 1.34 (0.80, 2.22) for antidepressants.

CONCLUSIONS

We observed high levels of outdoor WTN to be associated with redemption of sleep medication and antidepressants among the elderly, suggesting that WTN may potentially be associated with sleep and mental health. https://doi.org/10.1289/EHP3909.

摘要

背景

风力涡轮机(WT)产生的噪音与烦恼有关,并且可能会扰乱睡眠。

目的

我们的目的是调查长期 WT 噪声(WTN)暴露是否与睡眠药物和抗抑郁药的处方赎回有关。

方法

对于半径为[公式:见文本]高度内的所有丹麦住宅,以及半径为[公式:见文本]高度内随机选择的 25%的住宅,我们使用 WT 类型和模拟的每小时风的信息来估算夜间室外和低频(LF)室内 WTN。在 1996 年至 2013 年的随访期间,分别从合格人群 583968 人和 584891 人中,有 68696 人赎回睡眠药物,82373 人赎回抗抑郁药。我们使用泊松回归,调整个体和区域水平的协变量。

结果

五年平均户外夜间 WTN 为[公式:见文本]与睡眠药物的风险比(HR)= 1.14(95%置信区间(CI):0.98,1.33)和抗抑郁药的 HR = 1.17(95% CI:1.01,1.35)(与 WTN 暴露[公式:见文本]相比)。我们没有发现夜间室内 LF WTN 的总体关联。在按年龄分层的分析中,与户外夜间 WTN 的关联在年龄在[公式:见文本]的人群中最强,最高暴露组([公式:见文本])的睡眠药物 HR(95%CI)为 1.68(1.27,2.21),抗抑郁药为 1.23(0.90,1.69)。对于夜间室内 LF WTN,暴露于[公式:见文本]的年龄在[公式:见文本]的人群中,睡眠药物的 HR(95%CI)为 1.37(0.81,2.31),抗抑郁药为 1.34(0.80,2.22)。

结论

我们观察到高水平的户外 WTN 与老年人睡眠药物和抗抑郁药的赎回有关,这表明 WTN 可能与睡眠和心理健康有关。https://doi.org/10.1289/EHP3909.

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