Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Gastroenterol. 2019 Jul 25;19(1):133. doi: 10.1186/s12876-019-1055-4.
The aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD).
Fifty patients with NAFLD were randomized to receive lifestyle modification advice plus either 1500 mg curcumin or the same amount of placebo for 12 weeks.
Curcumin supplementation was associated with significant decrease in hepatic fibrosis (p < 0.001), and nuclear factor-kappa B activity (p < 0.05) as compared with the baseline. Hepatic steatosis and serum level of liver enzymes, and tumor necrosis-α (TNF-α) significantly reduced in both groups (p < 0.05). None of the changes were significantly different between two groups.
Our results indicated that curcumin supplementation plus lifestyle modification is not superior to lifestyle modification alone in amelioration of inflammation.
IRCT20100524004010N24, this trial was retrospectively registered on May 14, 2018.
本研究旨在评估姜黄素补充对非酒精性脂肪性肝病（NAFLD）患者炎症指标和肝脏特征的影响。
50 例 NAFLD 患者随机分为两组，分别接受生活方式改变建议加 1500mg 姜黄素或相同量的安慰剂，疗程为 12 周。
与基线相比，姜黄素补充治疗可显著降低肝纤维化（p<0.001）和核因子-κB 活性（p<0.05）。两组患者的肝脂肪变性和血清肝酶及肿瘤坏死-α（TNF-α）水平均显著降低（p<0.05）。两组间的这些变化均无显著差异。
我们的结果表明，姜黄素补充加生活方式改变并不优于单纯的生活方式改变，在改善炎症方面。
IRCT20100524004010N24，本试验于 2018 年 5 月 14 日回顾性注册。
