Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109792. doi: 10.1016/j.msec.2019.109792. Epub 2019 May 25.
Curcumin has recently attracted much attention due to the wide range of its physiological actions such as anti-tumor, anti-inflammatory, anti-thrombotic, anti-diabetic and anti-microbial effects. This phytochemical can be used as a sensing material for the detection of chemicals due to its optical properties as a fluorescent polyphenol. Curcumin and its derivatives can make complexes with many cations such as Cu, Fe, Hg, Pt, Re and Alvia bearing 1,3-diketones with keto-enol isomerization. The complexation of curcumin with certain metal ions leads to its solubility in water and producing various hues of colors as well as cytotoxic and antimicrobial effects. Curcumin can also form complexes with certain metal ions and thus serve as a chelating agent for anions such as ClO, CN, F and S. Moreover, conjugation of curcumin with some organic compounds such as cysteine and poly-glycerol acrylate provides an efficient fluorescence detection system for picric acid and 2-vinyl pyridine in aqueous media. In this review, we focused on curcumin as a key element in a membrane composition of chemical sensors. In addition, the latest sensing platforms based on curcumin and its derivatives are briefly described.
姜黄素由于其广泛的生理作用,如抗肿瘤、抗炎、抗血栓形成、抗糖尿病和抗微生物作用,最近引起了广泛关注。这种植物化学物质可以用作化学物质检测的传感材料,因为它作为一种荧光多酚具有光学性质。姜黄素及其衍生物可以与许多阳离子形成配合物,例如 Cu、Fe、Hg、Pt、Re 和 Alvia,这些阳离子带有酮-烯醇互变异构的 1,3-二酮。姜黄素与某些金属离子的络合导致其在水中的溶解度增加,并产生各种色调的颜色以及细胞毒性和抗菌作用。姜黄素还可以与某些金属离子形成配合物,从而充当阴离子如 ClO、CN、F 和 S 的螯合剂。此外,姜黄素与半胱氨酸和聚甘油丙烯酸酯等某些有机化合物的共轭提供了一种在水介质中检测苦味酸和 2-乙烯基吡啶的高效荧光检测系统。在这篇综述中,我们重点介绍了姜黄素作为化学传感器膜组成部分的关键元素。此外,还简要描述了基于姜黄素及其衍生物的最新传感平台。