Malacaria Luana, Corrente Giuseppina Anna, Beneduci Amerigo, Furia Emilia, Marino Tiziana, Mazzone Gloria
Department of Chemistry and Chemical Technologies, University of Calabria, Via P. Bucci, I-87036 Rende, CS, Italy.
Molecules. 2021 Apr 29;26(9):2603. doi: 10.3390/molecules26092603.
This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal's intake and/or its removal in living organisms.
本综述聚焦于某些天然抗氧化分子（即羟基肉桂酸、香豆素 - 3 - 羧酸、槲皮素、木犀草素和姜黄素）形成铝（III）和铁（III）配合物的能力，旨在从实验和理论相结合的角度评估配位性质。尽管先前关于涉及此类天然抗氧化剂的这些金属配合物的化学性质和生物活性的研究有所贡献，但结构与性质之间仍需要进一步详细的关系。在此背景下，对铝（III）和铁（III）与这些天然抗氧化分子的配位性质的研究，对于设计能够改善生物体中金属摄取和/或去除的水溶性分子基金属载体可能具有很高的研究价值。
