Laboratory of Histocompatibility, Unidad Médica de Alta Especialidad (UMAE) # 71, Instituto Mexicano del Seguro Social (IMSS), Torreón, Coahuila, Mexico.
Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany. Electronic address: http://www.shh.mpg.de/en.
Hum Immunol. 2020 Sep;81(9):492-495. doi: 10.1016/j.humimm.2019.07.284. Epub 2019 Jul 23.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N = 72), Torreón (N = 396) and rural communities (N = 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72 ± 4.18% by ML; 37.49% of European haplotypes) and Native American (45.01 ± 2.69% by ML; 42.98% of Native American haplotypes), while African genetic component is less apparent (5.27 ± 1.88% by ML; 9.92% of African haplotypes).
我们通过 PCR-SSP 基于分型的方法对来自科阿韦拉州居住在萨利托（N=72）、托雷翁（N=396）和农村社区（N=216）的 684 名墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因研究，以获得有关等位基因和单倍型频率的信息。我们发现，在科阿韦拉州发现的 10 个最常见的单倍型包括 8 个美洲原住民和 2 个欧洲单倍型。混合估计表明，科阿韦拉州的主要遗传成分是欧洲（最大似然法 ML 为 49.72±4.18%；欧洲单倍型占 37.49%）和美洲原住民（ML 为 45.01±2.69%；美洲原住民单倍型占 42.98%），而非洲遗传成分则不那么明显（ML 为 5.27±1.88%；非洲单倍型占 9.92%）。
