墨西哥新莱昂两群体的 HLA 系统遗传多样性：蒙特雷和新莱昂农村。
Genetic diversity of HLA system in two populations from Nuevo León, Mexico: Monterrey and rural Nuevo León.
机构信息
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Blood Bank, Unidad Médica de Alta Especialidad (UMAE) Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):516-518. doi: 10.1016/j.humimm.2019.06.003. Epub 2019 Jun 11.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo León living in the city of Monterrey (N = 226) and rural communities (N = 439), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Nuevo León include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nuevo León are Native American (54.53 ± 0.87% by ML; 48.88% of Native American haplotypes) and European (38.67 ± 4.06% by ML; 32.59% of European haplotypes), and a less prominent African genetic component (6.80 ± 4.30% by ML; 8.26% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自新莱昂州的 665 名生活在蒙特雷市（N=226）和农村社区（N=439）的墨西哥人进行了 HLA I 类（HLA-A、-B）和 II 类（HLA-DRB1、-DQB1）等位基因研究，以获得有关等位基因和单倍型频率的信息。我们发现，新莱昂州最常见的单倍型包括 12 个美洲原住民和 3 个欧洲单倍型。混合估计表明，新莱昂州的主要遗传成分是美洲原住民（ML 法的 54.53±0.87%；48.88%的美洲原住民单倍型）和欧洲人（ML 法的 38.67±4.06%；32.59%的欧洲人单倍型），以及一个不太明显的非洲遗传成分（ML 法的 6.80±4.30%；8.26%的非洲人单倍型）。
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