墨西哥伊达尔戈州两个群体的 HLA 系统遗传多样性：帕丘卡和伊达尔戈农村。
Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo.
机构信息
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE) Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
出版信息
Hum Immunol. 2020 Sep;81(9):535-538. doi: 10.1016/j.humimm.2019.07.293. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 122 Mexicans from the state of Hidalgo living in the city of Pachuca (N = 41) and rural communities (N = 81), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in Hidalgo include eight Native American and one European haplotypes. Admixture estimates revealed that the main genetic components in Hidalgo are Native American (58.93 ± 2.16% by ML; 54.51% of Native American haplotypes) and European (32.49 ± 2.88% by ML; 28.69% of European haplotypes), and a relatively high African genetic component (8.58 ± 0.93% by ML; 6.97% of African haplotypes).
我们通过 PCR-SSP 基于分型的方法研究了 122 名来自哈利斯科州的墨西哥人（居住在帕丘卡市的有 41 人，居住在农村社区的有 81 人）的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获得有关等位基因和单倍型频率的信息。我们发现，哈利斯科州最常见的单倍型包括 8 个美洲原住民和 1 个欧洲单倍型。混合估计显示，哈利斯科州的主要遗传成分是美洲原住民（最大似然法为 58.93±2.16%；54.51%的美洲原住民单倍型）和欧洲人（最大似然法为 32.49±2.88%；28.69%的欧洲人单倍型），以及相对较高的非洲遗传成分（最大似然法为 8.58±0.93%；6.97%的非洲人单倍型）。
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