Department of Molecular Biology, Laboratorios Diagnóstica, Villahermosa, Tabasco, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: http://www.shh.mpg.de/en.
Hum Immunol. 2020 Sep;81(9):560-562. doi: 10.1016/j.humimm.2019.07.286. Epub 2019 Jul 23.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79 ± 1.59% by ML; 56.25% of Native American haplotypes) and European (27.21 ± 3.97% by ML; 29.91% of European haplotypes), and a less prominent African genetic component (5.01 ± 4.42% by ML; 8.93% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法，对来自塔巴斯科州的 224 名居住在比亚埃尔莫萨市（82 人）和农村社区（142 人）的墨西哥人进行了 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因分析，以获取有关等位基因和单倍型频率的信息。结果发现，塔巴斯科州最常见的单倍型包括 13 种美洲原住民和 2 种欧洲单倍型。混合估计表明，塔巴斯科州的主要遗传成分是美洲原住民（ML 法的 67.79±1.59%；56.25%的美洲原住民单倍型）和欧洲人（ML 法的 27.21±3.97%；29.91%的欧洲人单倍型），以及不太明显的非洲遗传成分（ML 法的 5.01±4.42%；8.93%的非洲人单倍型）。
