Molecular Biology Laboratory, Hospital General "Norberto Treviño Zapata", Dirección de Servicios de Salud de Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.
Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Hum Immunol. 2020 Sep;81(9):525-527. doi: 10.1016/j.humimm.2019.07.288. Epub 2019 Jul 22.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 148 Mexicans from the state of Tamaulipas living in Ciudad Victoria (N = 23) and rural communities (N = 125), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Tamaulipas include ten Native American, three European and one African haplotypes. Admixture estimates revealed that the main genetic components in the state of Tamaulipas are Native American (54.69 ± 0.93% by ML; 47.65% of Native American haplotypes) and European (34.66 ± 5.62% by ML; 33.56% of European haplotypes), and a relatively high African genetic component (10.65 ± 5.05% by ML; 12.42% of African haplotypes).
我们通过 PCR-SSP 基于分型的方法研究了来自塔毛利帕斯州居住在维多利亚城（N=23）和农村社区（N=125）的 148 名墨西哥人的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获取有关等位基因和单倍型频率的信息。我们发现，塔毛利帕斯州最常见的单倍型包括 10 个美洲原住民、3 个欧洲和 1 个非洲单倍型。混合估计显示，塔毛利帕斯州的主要遗传成分是美洲原住民（ML 法为 54.69±0.93%；美洲原住民单倍型占 47.65%）和欧洲（ML 法为 34.66±5.62%；欧洲单倍型占 33.56%），以及相对较高的非洲遗传成分（ML 法为 10.65±5.05%；非洲单倍型占 12.42%）。
