Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Laboratory of Histocompatibility, Unidad Médica de Alta Especialidad (UMAE) #71, Instituto Mexicano del Seguro Social (IMSS), Torreón, Coahuila, Mexico.
Hum Immunol. 2020 Sep;81(9):485-488. doi: 10.1016/j.humimm.2019.05.014. Epub 2019 Jun 4.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N = 119), Ciudad Juárez (N = 106) and rural communities (N = 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 ± 0.88% by ML; 41.53% of European haplotypes) and Native American (39.51 ± 2.17% by ML; 37.45% of Native American haplotypes), while African genetic component was less apparent (8.36 ± 1.47% by ML; 11.70% of African haplotypes).
我们通过基于 PCR-SSP 的分型方法研究了来自奇瓦瓦州的 461 名墨西哥人（其中 119 人居住在奇瓦瓦市，106 人居住在华雷斯城，236 人居住在农村社区）的 HLA Ⅰ类（HLA-A、-B）和Ⅱ类（HLA-DRB1、-DQB1）等位基因，以获取有关等位基因和单倍型频率及其连锁不平衡的信息。我们发现，在奇瓦瓦州发现的最常见的单倍型包括七个美洲原住民和三个欧洲单倍型。混合估计表明，奇瓦瓦州的主要遗传成分是欧洲（最大似然法[ML]下为 52.12 ± 0.88%；欧洲单倍型的 41.53%）和美洲原住民（ML 下为 39.51 ± 2.17%；美洲原住民单倍型的 37.45%），而非洲遗传成分则不太明显（ML 下为 8.36 ± 1.47%；非洲单倍型的 11.70%）。
