Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan 250061, People's Republic of China.
Nanoscale. 2019 Oct 10;11(39):17967-17980. doi: 10.1039/c9nr04301b.
Au nanoclusters possess a series of excellent properties owing to their size being comparable to the Fermi wavelength of electrons. For example, they show excellent biocompatibility, optical stability, large Stokes shift, intense size-dependent emission and monodispersion, and thus could effectively compensate for the shortcomings of traditional organic fluorescent dyes and fluorescent quantum. In this review, we detail the latest developments of Au nanoclusters employed in the field of biomedicine, especially in oncology research, by summarizing the application of imaging, sensing and drug delivery based on their excellent luminescent properties and unique structural features. We also discuss the significant work relating to Au NCs that now is being devoted in other therapeutic strategies, such as radiotherapy, photothermal therapy and photodynamic therapy, for example. It is anticipated that this review will provide new insights and theoretical guidance to allow the advantages of Au nanoclusters to be realized in oncotherapy.
金纳米团簇由于其尺寸与电子的费米波长相当，因此具有一系列优异的性质。例如，它们表现出优异的生物相容性、光学稳定性、大斯托克斯位移、强烈的尺寸依赖性发射和单分散性，因此可以有效弥补传统有机荧光染料和荧光量子点的缺点。在本文中，我们详细介绍了金纳米团簇在生物医学领域，特别是在肿瘤研究中的最新进展，通过总结基于其优异发光性能和独特结构特征的成像、传感和药物输送的应用，来阐述其在生物医学领域的应用。我们还讨论了与 Au NCs 相关的重要工作，例如放射治疗、光热治疗和光动力治疗等其他治疗策略。我们希望这篇综述将为实现金纳米团簇在肿瘤治疗中的优势提供新的见解和理论指导。
