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Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis.

作者信息

Papadimitriou C S, Ioachim-Velogianni E E, Tsianos E B, Moutsopoulos H M

机构信息

Department of Anatomic Pathology, School of Medicine, University of Ioannina, Greece.

出版信息

Virchows Arch A Pathol Anat Histopathol. 1988;413(3):197-204. doi: 10.1007/BF00718611.

DOI:10.1007/BF00718611
PMID:3135657
Abstract

Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa was found in all cases closely related to mononuclear infiltrates. Epithelial HLA-DR expression and mononuclear infiltrates were practically absent in foci of intestinal metaplasia. These findings suggest that an immunopathologic mechanism probably plays a role in initiation or perpetuation of type-B chronic gastritis.

摘要

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Expression of MHC class II antigens (HLA-DR, -DP, and -DQ) on human gastric epithelium.人类胃上皮细胞上主要组织相容性复合体II类抗原（HLA-DR、-DP和-DQ）的表达
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