Martínez-González Agustín Ernesto, Andreo-Martínez Pedro
Department of Developmental Psychology and Didactics, University of Alicante, 03080 Alicante, Spain.
Department of Agricultural Chemistry, Faculty of Chemistry, University of Murcia, Campus of Espinardo, 30100 Murcia, Spain.
Medicina (Kaunas). 2019 Jul 26;55(8):408. doi: 10.3390/medicina55080408.
: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction disorder, and repetitive behavior. Dysbiotic gut microbiota (GM) could be a contributing factor to the appearance of ASD, as gastrointestinal (GI) symptoms are comorbidities frequently reported in ASD. As there is a lack of reviews about the role played by GM in the GI symptoms of ASD, this work aimed to carry out a systematic review of current studies comparing the GM of children with ASD and GI symptoms with those of healthy controls in the last six years. The systematic review was performed following the PRISMA guidelines. The databases chosen were Web of Science, Scopus, PubMed, and PsycINFO, and the keywords were (gut* OR intestine* OR bowel* OR gastrointestinal*) AND (microbiota* OR microflora* OR bacteria* OR microbiome* OR flora* OR bacterial* OR bacteria* OR microorganism* OR feces* OR stool*) AND (autistic* OR autism* OR ASD*). : A total of 16 articles were included. Ten articles performed correlations analysis between GI symptoms and ASD. Among those 10 articles, 7 found differences between the GI symptoms present in children with ASD and healthy controls. The most common GI symptom was constipation. Among the seven articles that found differences, three performed correlations analysis between GI symptoms and gut microbe abundance. , , , and showed higher and lower abundance, respectively, in children with ASD and GI symptoms in more than one article. , , , , , , and / ratios showed abundance discrepancies. : It is still too early to draw a conclusion about the gut microbes involved in GI symptoms of ASD. Future research should consider the relationship between ASD behavior, GM, and GI symptoms in a multidisciplinary way and homogenize sample characteristics.
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征为沟通障碍、社交互动障碍和重复行为。肠道微生物群失调（GM）可能是ASD出现的一个促成因素，因为胃肠道（GI）症状是ASD中经常报告的共病。由于缺乏关于GM在ASD的GI症状中所起作用的综述，这项工作旨在对过去六年中比较患有ASD和GI症状的儿童与健康对照的GM的现有研究进行系统综述。系统综述按照PRISMA指南进行。选择的数据库是Web of Science、Scopus、PubMed和PsycINFO，关键词为（gut或intestine或bowel或gastrointestinal）AND（microbiota或microflora或bacteria或microbiome或flora或bacterial或bacteria或microorganism或feces或stool）AND（autistic或autism或ASD*）。共纳入16篇文章。10篇文章对GI症状与ASD之间进行了相关性分析。在这10篇文章中，7篇发现患有ASD的儿童和健康对照的GI症状存在差异。最常见的GI症状是便秘。在发现差异的7篇文章中，3篇对GI症状与肠道微生物丰度之间进行了相关性分析。在不止一篇文章中，分别显示患有ASD和GI症状的儿童中丰度较高和较低。、、、、、和/比率显示丰度存在差异。关于涉及ASD的GI症状的肠道微生物得出结论仍为时过早。未来的研究应以多学科方式考虑ASD行为、GM和GI症状之间的关系，并使样本特征同质化。
