一项关于拔牙后位点使用的不同可吸收和不可吸收骨替代材料的人体临床和组织形态计量学研究。初步结果。
A Human Clinical and Histomorphometrical Study on Different Resorbable and Non-Resorbable Bone Substitutes Used in Post-Extractive Sites. Preliminary Results.
作者信息
De Tullio Ilaria, Caputi Sergio, Perfetti Giorgio, Mavriqi Luan, Wismeijer Daniel, Traini Tonino
机构信息
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Department of Oral Surgery and Implantology, University "ALDENT" of Tirana, 1023 Tirana, Albania.
出版信息
Materials (Basel). 2019 Jul 28;12(15):2408. doi: 10.3390/ma12152408.
BACKGROUND
The healing of sockets following teeth extraction results in a marked reduction of the height and width of the ridge. This in vivo study aims to assess and compare the efficacy of calcium sulphate (CS) and sintered nano-hydroxyapatite (NHA) in postextraction sockets.
MATERIALS AND METHODS
10 subjects were enrolled for single or multiple tooth extraction and implant placement. Each site was randomly assigned to one of four groups and filled with CS, NHA, a combination of CS and NHA, or left to normal healing. After five months tissue samples were harvested from the extraction sites and prepared for histological investigations.
RESULTS
Histomorphometric analysis showed that the average percentages of vital bone was 13.56% ± 13.08% for CS, 17.84% ± 7.32% for NHA, 58.72% ± 8.77% for CS + NHA%, and 80.68% ± 21.8% for the controls; for the connective tissue the results were 33.25% ± 35.75% for CS, 55.88% ± 21.86% for NHA, 17.34% ± 8.51% for CS + NHA, and 22.62% ± 0.52% for the controls; for residual biomaterial the results were 0.56% ± 0.52% for CS group, 21.97% ± 0.79% for NHA, and 47.54% ± 20.13% for CS + NHA. : Both biomaterials led to bone tissue formation after five months of healing. The combination of the biomaterials presented a better behavior when compared to the individual application.
背景
拔牙后牙槽窝的愈合会导致牙槽嵴高度和宽度显著降低。本体内研究旨在评估和比较硫酸钙（CS）和烧结纳米羟基磷灰石（NHA）在拔牙后牙槽窝中的疗效。
材料与方法
招募10名受试者进行单颗或多颗牙齿拔除及种植体植入。每个部位随机分为四组之一，分别填充CS、NHA、CS与NHA的组合，或任其自然愈合。五个月后，从拔牙部位采集组织样本，准备进行组织学研究。
结果
组织形态计量学分析显示，CS组活骨的平均百分比为13.56%±13.08%，NHA组为17.84%±7.32%，CS+NHA组为58.72%±8.77%，对照组为80.68%±21.8%；结缔组织方面，CS组结果为为33.25%±35.75%，NHA组为55.88%±21.86%，CS+NHA组为17.34%±8.51%，对照组为22.62%±0.52%；残留生物材料方面，CS组结果为0.56%±0.52%，NHA组为21.97%±0.79%，CS+NHA组为47.54%±20.13%。两种生物材料在愈合五个月后均导致骨组织形成。与单独应用相比，生物材料的组合表现出更好的效果。
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