新的酒精相关基因表明与神经精神疾病存在共同的遗传机制。
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
机构信息
Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
出版信息
Nat Hum Behav. 2019 Sep;3(9):950-961. doi: 10.1038/s41562-019-0653-z. Epub 2019 Jul 29.
Abstract
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
摘要
过量饮酒是全球范围内导致死亡和残疾的主要原因之一。饮酒是一种可遗传的复杂特征。在这里，我们对来自英国生物银行、酒精基因组广泛联盟和基因组流行病学加队列的心脏和衰老研究队列的饮酒（g d）全基因组关联研究进行了荟萃分析，从欧洲血统的 480,842 人收集数据，以破译酒精摄入量的遗传结构。我们确定了 46 个新的常见基因座，并使用磁共振成像数据和基因表达研究调查了它们的潜在功能重要性。我们确定了与饮酒相关的遗传途径，并提出了与精神分裂症等神经精神障碍共享的遗传机制。
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