Chen Shi-Lin, Wu Wen-Guang, Wang Cai-Xia, Xiang Li, Shi Yu-Hua, Zhang Dong, Hu Hao-Yu
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(12):2421-2432. doi: 10.19540/j.cnki.cjcmm.20190514.102.
With the development of various biotechnology,the research on molecular genetics of medicinal plants has gradually deepened. In this paper,the research system of molecular genetics of medicinal plants was proposed for the first time,which was elaborated from the aspects of genetic resources,genome,gene function and research methods. The application fields of medicinal plant mainly contain species identification,molecular breeding and biosynthesis. The research directions of molecular genetics of medicinal plants in genetic resources,model platform,synthetic biology and molecular breeding were put forward,which include 1 000 genome projects of medicinal plants,model species and mutant libraries,gene original libraries of heterologous synthetic systems,construction gene original library and specific chassis cells in heterologous synthesis system of active ingredient,breeding of new varieties of medicinal plants with high active ingredient and high resistance based on molecular markers andtransgenes.
随着各种生物技术的发展，药用植物分子遗传学研究逐渐深入。本文首次提出了药用植物分子遗传学研究体系，并从遗传资源、基因组、基因功能及研究方法等方面进行了阐述。药用植物的应用领域主要包括物种鉴定、分子育种和生物合成。提出了药用植物分子遗传学在遗传资源、模式平台、合成生物学和分子育种等方面的研究方向，包括药用植物千基因组计划、模式物种及突变体库、异源合成系统基因原件库、活性成分异源合成系统中构建基因原件库及特定底盘细胞、基于分子标记和转基因培育高活性成分和高抗性药用植物新品种。
