1,2 - 二甲基肼诱导的大鼠肿瘤中的DNA倍性
DNA ploidy in 1,2-dimethylhydrazine-induced rat tumors.
作者信息
Sano T, Remvikos Y, Vielh P, Buisson J P, Manceau R, Salmon R J
机构信息
Department of Medicine, Institut Curie, Paris, France.
出版信息
Jpn J Cancer Res. 1988 May;79(5):580-3. doi: 10.1111/j.1349-7006.1988.tb00025.x.
Abstract
The DNA content of 1,2-dimethylhydrazine (DMH)-induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S-phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma-carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers.
摘要
采用流式细胞术分析了1,2 - 二甲基肼（DMH）诱导的雄性Wistar大鼠肠道肿瘤的DNA含量。所有腺瘤和癌均为DNA二倍体。肿瘤的S期分数与正常黏膜的S期分数无显著差异。在我们的系列研究中观察到了腺瘤 - 癌序列的组织学证据。缺乏DNA非整倍体是DMH模型与人类结直肠癌之间的主要差异之一。
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