1,2 - 二甲基肼诱导的大鼠肿瘤中的DNA倍性
DNA ploidy in 1,2-dimethylhydrazine-induced rat tumors.
作者信息
Sano T, Remvikos Y, Vielh P, Buisson J P, Manceau R, Salmon R J
机构信息
Department of Medicine, Institut Curie, Paris, France.
出版信息
Jpn J Cancer Res. 1988 May;79(5):580-3. doi: 10.1111/j.1349-7006.1988.tb00025.x.
Abstract
The DNA content of 1,2-dimethylhydrazine (DMH)-induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S-phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma-carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers.
摘要
采用流式细胞术分析了1,2 - 二甲基肼（DMH）诱导的雄性Wistar大鼠肠道肿瘤的DNA含量。所有腺瘤和癌均为DNA二倍体。肿瘤的S期分数与正常黏膜的S期分数无显著差异。在我们的系列研究中观察到了腺瘤 - 癌序列的组织学证据。缺乏DNA非整倍体是DMH模型与人类结直肠癌之间的主要差异之一。
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Cancer. 1981 Jan 1;47(1):81-9. doi: 10.1002/1097-0142(19810101)47:1<81::aid-cncr2820470115>3.0.co;2-t.
2
Convention on nomenclature for DNA cytometry. Committee on Nomenclature, Society for Analytical Cytology.DNA细胞计量学命名法公约。分析细胞学会命名委员会
Cancer Genet Cytogenet. 1984 Oct;13(2):181-3. doi: 10.1016/0165-4608(84)90059-1.
3
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J Histochem Cytochem. 1981 Jan;29(1):74-8. doi: 10.1177/29.1.6162882.
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Cancer Res. 1985 Jul;45(7):3392-7.
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8
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