Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Protein Sci. 2020 Jan;29(1):8-18. doi: 10.1002/pro.3702. Epub 2019 Aug 10.
This article is written for the 2020 tool issue of Protein Science. It briefly introduces the widely used antimicrobial peptide database, initially online in 2003. After a description of the main features of each database version and some recent additions, the focus is on the peptide design parameters for each of the four unified classes of natural antimicrobial peptides (AMPs). The amino acid signature in AMPs varies substantially, leading to a variety of structures for functional and mechanistic diversity. Also, Nature is a master of combinatorial chemistry by deploying different amino acids onto the same structural scaffold to tune peptide functions. In addition, the single-domain AMPs may be posttranslationally modified, self-assembled, or combined with other AMPs for function. Elucidation of the design principles of natural AMPs will facilitate future development of novel molecules for various applications.
本文是为 2020 年蛋白质科学工具问题而写的。它简要介绍了广泛使用的抗菌肽数据库，该数据库最初于 2003 年在线。在描述了每个数据库版本的主要特点和一些最近的补充之后，重点介绍了四类统一的天然抗菌肽 (AMPs) 的每个肽设计参数。抗菌肽中的氨基酸特征变化很大，导致功能和机制多样性的各种结构。此外，大自然通过将不同的氨基酸部署到相同的结构支架上来调整肽的功能，是组合化学的大师。此外，单一结构域的 AMP 可能会发生翻译后修饰、自组装或与其他 AMP 结合以发挥功能。阐明天然 AMP 的设计原则将有助于未来开发用于各种应用的新型分子。
