Vazeille M C, Rosen L, Guillon J C
Arbovirus Program, Pacific Biomedical Research Center, University of Hawaii, Honolulu 96822.
J Virol. 1988 Sep;62(9):3484-7. doi: 10.1128/JVI.62.9.3484-3487.1988.
An orbivirus, JKT-7400, isolated from Culex mosquitoes in Indonesia, replicated to a high titer and induced cytopathic effects in Aedes albopictus cell cultures. The virus produced lethal sensitivity to carbon dioxide in Culex and Aedes mosquitoes as well as in Drosophila melanogaster fruit flies but was not the agent of the hereditary sensitivity to carbon dioxide previously described for Culex quinquefasciatus. When injected intravenously in high doses, JKT-7400 virus was lethal for rabbits, apparently without replicating to a significant extent. It was not pathogenic for adult mice inoculated intravenously or for adult or suckling mice inoculated intracerebrally and intraperitoneally. Unlike an orbivirus isolated from Culex mosquitoes in China, JKT-7400 did not interfere with the replication of Japanese encephalitis virus in mosquitoes.
从印度尼西亚库蚊中分离出的一种环状病毒JKT - 7400，在白纹伊蚊细胞培养物中能高效复制并产生细胞病变效应。该病毒对库蚊、伊蚊以及黑腹果蝇产生对二氧化碳的致死敏感性，但并非先前描述的致库蚊对二氧化碳遗传性敏感的病原体。当高剂量静脉注射时，JKT - 7400病毒对兔子具有致死性，显然并未大量复制。它对静脉接种的成年小鼠或脑内及腹腔接种的成年或乳鼠均无致病性。与从中国库蚊中分离出的一种环状病毒不同，JKT - 7400不会干扰日本脑炎病毒在蚊子中的复制。
