新型裂解副溶血性弧菌噬菌体 vB_VpP_BA6 的基因组特征。
Genome characterization of the novel lytic Vibrio parahaemolyticus phage vB_VpP_BA6.
机构信息
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbiology Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Xianlie Zhong Road 100, Guangzhou, 510070, Guangdong, China.
College of Agriculture, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, China.
出版信息
Arch Virol. 2019 Oct;164(10):2627-2630. doi: 10.1007/s00705-019-04351-5. Epub 2019 Jul 30.
A lytic bacteriophage, designated Vibrio phage vB_VpP_BA6, was isolated from sewage collected in Guangzhou, China. The double-stranded DNA genome of phage BA6 is composed of 50,520 bp with a G+C content of 41.77%. It possesses 64 open reading frames relating to phage structure, packaging, host lysis, DNA metabolism, and additional functions. Three tRNAs genes (encoding Pro, Ile and Trp) were detected. Comparison of its genomic features and phylogenetic analysis revealed that phage BA6 is a novel member of the family Podoviridae. This phage may represent a potential therapeutic agent against multidrug-resistant Vibrio parahaemolyticus.
一种裂解性噬菌体，被命名为 Vibrio 噬菌体 vB_VpP_BA6，从中国广州采集的污水中分离得到。噬菌体 BA6 的双链 DNA 基因组由 50520bp 组成，G+C 含量为 41.77%。它拥有 64 个与噬菌体结构、包装、宿主裂解、DNA 代谢和其他功能相关的开放阅读框。检测到三个 tRNA 基因（编码 Pro、Ile 和 Trp）。对其基因组特征的比较和系统发育分析表明，噬菌体 BA6 是 Podoviridae 科的一个新成员。这种噬菌体可能代表一种针对多重耐药性副溶血性弧菌的潜在治疗剂。
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