Kobayashi Daiki, Takahashi Osamu, Shimbo Takuro
Division of General Internal Medicine, Department of Medicine, St. Luke's International Hospital, Tokyo, Japan
Department of Epidemiology, St. Luke's International University Graduate School of Public Health, Tokyo, Japan.
Anticancer Res. 2019 Aug;39(8):4415-4421. doi: 10.21873/anticanres.13613.
BACKGROUND/AIM: The aim of this study was to evaluate the association between the frequency of daily tooth brushing and the development of any type of malignancy.
We conducted a retrospective longitudinal study, including all adult participants who underwent health check-ups. Primary outcome was the development of any type of malignancy, compared to the frequency of daily tooth brushing, adjusting for potential confounders.
A total of 71,449 participants were included and 5,025 participants developed a certain type of malignancy. Not brushing everyday (Odds Ratio (OR)=1.52, 95% Confidence Interval (CI)=1.03-2.25) and brushing once a day (OR=1.25, 95%CI=1.16-1.35) had significantly higher ORs for the outcome than brushing after every meal, although those who brushed once to twice a day had significantly lower OR (OR=0.78, 95%CI=0.72-0.83).
As the frequency of daily tooth brushing increased, except for brushing after every meal, the development of all types of malignancies decreased.
背景/目的：本研究旨在评估每日刷牙频率与任何类型恶性肿瘤发生之间的关联。
我们进行了一项回顾性纵向研究，纳入所有接受健康检查的成年参与者。主要结局是任何类型恶性肿瘤的发生情况，与每日刷牙频率进行比较，并对潜在混杂因素进行校正。
共纳入71449名参与者，其中5025名参与者发生了某种类型的恶性肿瘤。与每餐饭后刷牙相比，不每天刷牙（比值比（OR）=1.52，95%置信区间（CI）=1.03 - 2.25）和每天刷牙一次（OR = 1.25，95%CI = 1.16 - 1.35）的结局OR值显著更高，尽管每天刷牙一到两次的参与者OR值显著更低（OR = 0.78，95%CI = 0.72 - 0.83）。
随着每日刷牙频率增加，除每餐饭后刷牙外，所有类型恶性肿瘤的发生均减少。
